Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE(toxin)
Location 994999..995558 Replicon chromosome
Accession NZ_CP075192
Organism Ferribacterium limneticum strain 132

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KI608_RS04780 Protein ID WP_226450880.1
Coordinates 994999..995247 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KI608_RS04785 Protein ID WP_226450881.1
Coordinates 995244..995558 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI608_RS04755 (KI608_04755) 990048..992324 - 2277 WP_226450876.1 PAS domain-containing sensor histidine kinase -
KI608_RS04760 (KI608_04760) 992391..992564 - 174 WP_226450877.1 hypothetical protein -
KI608_RS04765 (KI608_04765) 992601..993293 + 693 WP_226450878.1 hypothetical protein -
KI608_RS04770 (KI608_04770) 993362..994606 + 1245 WP_226450879.1 spore maturation protein -
KI608_RS04780 (KI608_04780) 994999..995247 + 249 WP_226450880.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KI608_RS04785 (KI608_04785) 995244..995558 + 315 WP_226450881.1 hypothetical protein Antitoxin
KI608_RS04790 (KI608_04790) 995757..996332 + 576 WP_226450882.1 pseudouridine synthase -
KI608_RS04795 (KI608_04795) 996325..996768 + 444 WP_226450883.1 DUF192 domain-containing protein -
KI608_RS04800 (KI608_04800) 996768..997298 + 531 WP_226450884.1 chorismate lyase -
KI608_RS04805 (KI608_04805) 997337..998203 + 867 WP_226450885.1 alpha/beta hydrolase -
KI608_RS04810 (KI608_04810) 998251..998505 - 255 WP_226450886.1 hypothetical protein -
KI608_RS04815 (KI608_04815) 998504..1000054 + 1551 WP_226450887.1 alkaline phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(25-76)

Antitoxin

Cro/C1-type helix-turn-helix domain

(42-101)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9507.98 Da        Isoelectric Point: 10.6178

>T203377 WP_226450880.1 NZ_CP075192:994999-995247 [Ferribacterium limneticum]
MLKNPKAGDVIEGTGGLRKLRHGDPRRGKGKRGGLRVIYYWWDGGRQFWLFTLYDKDEMENLSADEKKALRGMLKAELEA
RR

Download         Length: 249 bp

>T203377 NZ_CP099975:1925158-1925454 [Halomonas sp. Y3]
ATGAGCGACAAGATTTTTGACTACGACCCGGCAGCCGCCCTGGAAAGCGAGGAAGCGATTGCGGTATTTCTGGCGGATGC
CCTGGAAACAGGAGACTCCGCCTACATTGCCAAGGCGATGGGTGTAGTAGCACGCGCCAAAGGCATGAGCGAGCTCGCCC
GGGAAACCGGACTTTCCCGTGAGCAGCTGTATCGCTCTTTCAGTGAGCAGGGGAATCCCACGCTGAAAACCATGCTGGCC
GTGATGCGAGCCCTTGGCGTTGACTTGACGGCTCGCCCGCACGAGCCGGCTGCTTAG

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11835.64 Da        Isoelectric Point: 10.2615

>AT203377 WP_226450881.1 NZ_CP075192:995244-995558 [Ferribacterium limneticum]
MKKRNLFAEIAEGFDALANERTGKQTLRTHKVEVLPLAEVTAEELVSLRERLHLSRPVFAGYLRTNPRTLENWEQGRAKP
NAQASLLIRLVEKFPDTVERLAAV

Download         Length: 315 bp

>AT203377 NZ_CP099975:1924862-1925161 [Halomonas sp. Y3]
ATGCTCGATATTAAACAAACAGACACGTACCGAAAATGGGAGCGTAAGCTGCGAGATCAACGCGCCAAGGCGCTGATTGC
AGCGCGTGTTTTCCGCCTCGCCAATGGCTTGCCAGGGGATGTCCAGCCTGTAGGGCAGGGCGTCAGCGAGCTACGCATTC
ATCATGGTCCTGGCTATCGTATCTATTTCAAACAGCGCGGCAGCGAAATTGTCATCCTTCTGTGTGGTGGCGACAAGAGT
ACGCAGCAGCGCGATATCGAGACAGCACAGCGTCTTGCAGCAGAGTGGGAGGCCTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References