Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 3181544..3182015 Replicon chromosome
Accession NZ_CP075191
Organism Ferribacterium limneticum strain 128

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KI617_RS15265 Protein ID WP_264180020.1
Coordinates 3181544..3181720 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KI617_RS15270 Protein ID WP_226447691.1
Coordinates 3181704..3182015 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI617_RS15250 (KI617_15235) 3178153..3179367 - 1215 WP_226447685.1 nitrate/nitrite transporter -
KI617_RS15255 (KI617_15240) 3179860..3181356 + 1497 WP_226447687.1 reverse transcriptase family protein -
KI617_RS15260 3181349..3181531 - 183 WP_226447689.1 hypothetical protein -
KI617_RS15265 3181544..3181720 + 177 WP_264180020.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KI617_RS15270 (KI617_15250) 3181704..3182015 + 312 WP_226447691.1 helix-turn-helix domain-containing protein Antitoxin
KI617_RS15275 (KI617_15255) 3182192..3182623 - 432 WP_226447693.1 hypothetical protein -
KI617_RS15280 (KI617_15260) 3182652..3184379 - 1728 WP_226447694.1 bifunctional protein-serine/threonine kinase/phosphatase -
KI617_RS15285 (KI617_15265) 3184505..3185317 - 813 WP_226447696.1 formate/nitrite transporter family protein -
KI617_RS15290 (KI617_15270) 3185411..3185722 - 312 WP_226447698.1 nitrite reductase small subunit NirD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(3-54)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-92)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6510.67 Da        Isoelectric Point: 10.9928

>T203374 WP_264180020.1 NZ_CP075191:3181544-3181720 [Ferribacterium limneticum]
MRKVRWSRAGSGKSGGVRVIYFTRNAVGEIVLLLLYAKSERDSMTAKQLLEIKNALDL

Download         Length: 177 bp

>T203374 NZ_CP099975:1815580-1815840 [Halomonas sp. Y3]
ATGAGGGTCGTGTCCTTTACCGAAGCAAGAAACGGGCTAAAGAGCGTGCTGGACAGTGTGATTAACGATGCCGATACGGC
CATCATTACACGTCGAGACTCTGAAGATGCCGTCGTGATGTCACTCGATTACTACAACAGCCTGATGGAAACCGTGCACC
TGCTTCGCTCCCCAGCGAATGCGGCACATCTGAACAAATCGATTGAGCAGTACCGTTCAGGAAAAGTCGTTGAGCGTAAG
TTGCTCGATGATGATGAGTAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11123.70 Da        Isoelectric Point: 6.4684

>AT203374 WP_226447691.1 NZ_CP075191:3181704-3182015 [Ferribacterium limneticum]
MPSTSNPMSDDDLAAFEAGRDLHADLLQSIREMKAGRGVVVLSPVIAARKASGLSQSQFAELMGVSVRTLQEWEQGRRQP
SGAALTLLKVAERHPEVLRELAA

Download         Length: 312 bp

>AT203374 NZ_CP099975:1815833-1816096 [Halomonas sp. Y3]
ATGAGTAATCGACTGCTGTGCTGGACGGATGAGTCATGGCGTGATTATGTCTATTGGCAACGTCAAGATAAGAAAACGCT
AAAGAGAATCAATAAGCTAATAGCGGACGTCAAGCGCTCGCCGTTTGAAGGTATTGGTAAGCCCGAGCCACTAAAGGAGA
ACCTGTCCGGTTTTTGGTCTCGACGCATTGACGAATCAAACCGACTGGTTTACGTGGTGGAGGAGTCTTCGATCACGATC
CTCTCTTGCAGGTACCACTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References