Detailed information of TA system TA203370

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE(toxin)
• Location: 994999..995558
• Replicon: chromosome
• Accession: NZ_CP075191
• Organism: Ferribacterium limneticum strain 128

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: KI617_RS04780
• Protein ID: WP_226450880.1
• Coordinates: 994999..995247 (+)
• Length: 83 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: KI617_RS04785
• Protein ID: WP_226450881.1
• Coordinates: 995244..995558 (+)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KI617_RS04755 (KI617_04755)	990048..992324	-	2277	WP_226450876.1	PAS domain-containing sensor histidine kinase	-
KI617_RS04760 (KI617_04760)	992391..992564	-	174	WP_226450877.1	hypothetical protein	-
KI617_RS04765 (KI617_04765)	992601..993293	+	693	WP_226450878.1	hypothetical protein	-
KI617_RS04770 (KI617_04770)	993362..994606	+	1245	WP_226450879.1	spore maturation protein	-
KI617_RS04780 (KI617_04780)	994999..995247	+	249	WP_226450880.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KI617_RS04785 (KI617_04785)	995244..995558	+	315	WP_226450881.1	hypothetical protein	Antitoxin
KI617_RS04790 (KI617_04790)	995757..996332	+	576	WP_226450882.1	pseudouridine synthase	-
KI617_RS04795 (KI617_04795)	996325..996768	+	444	WP_226450883.1	DUF192 domain-containing protein	-
KI617_RS04800 (KI617_04800)	996768..997298	+	531	WP_226450884.1	chorismate lyase	-
KI617_RS04805 (KI617_04805)	997337..998203	+	867	WP_226450885.1	alpha/beta hydrolase	-
KI617_RS04810 (KI617_04810)	998251..998505	-	255	WP_226450886.1	hypothetical protein	-
KI617_RS04815 (KI617_04815)	998504..1000054	+	1551	WP_226450887.1	alkaline phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (25-76)

Antitoxin

• Cro/C1-type helix-turn-helix domain (42-101)

Sequences

Toxin

Protein

• Length: 83 a.a.
• Molecular weight: 9507.98 Da
• Isoelectric Point: 10.6178

>T203370 WP_226450880.1 NZ_CP075191:994999-995247 [Ferribacterium limneticum]
MLKNPKAGDVIEGTGGLRKLRHGDPRRGKGKRGGLRVIYYWWDGGRQFWLFTLYDKDEMENLSADEKKALRGMLKAELEA
RR

Nucleotide

• Length: 249 bp

>T203370 NZ_CP099973:4490487-4490798 [Salmonella enterica subsp. enterica serovar Enteritidis]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACACTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGCACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATGATCGGGGTAATAAAGAATGA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 11835.64 Da
• Isoelectric Point: 10.2615

>AT203370 WP_226450881.1 NZ_CP075191:995244-995558 [Ferribacterium limneticum]
MKKRNLFAEIAEGFDALANERTGKQTLRTHKVEVLPLAEVTAEELVSLRERLHLSRPVFAGYLRTNPRTLENWEQGRAKP
NAQASLLIRLVEKFPDTVERLAAV

Nucleotide

• Length: 315 bp

>AT203370 NZ_CP099973:4490795-4491241 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAAGCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG