Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 3044470..3045066 Replicon chromosome
Accession NZ_CP075188
Organism Quatrionicoccus australiensis strain D9

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag KI612_RS14525 Protein ID WP_226440784.1
Coordinates 3044470..3044751 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KI612_RS14530 Protein ID WP_226440785.1
Coordinates 3044761..3045066 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI612_RS14500 (KI612_14555) 3040794..3041681 + 888 WP_226440779.1 nuclease-related domain-containing protein -
KI612_RS14505 (KI612_14560) 3041706..3042065 + 360 WP_226440780.1 hypothetical protein -
KI612_RS14510 (KI612_14565) 3042020..3043384 + 1365 WP_226440781.1 IS1182 family transposase -
KI612_RS14515 (KI612_14570) 3043517..3044149 + 633 WP_226440782.1 DUF4357 domain-containing protein -
KI612_RS14520 (KI612_14575) 3044195..3044407 + 213 WP_226440783.1 hypothetical protein -
KI612_RS14525 (KI612_14580) 3044470..3044751 + 282 WP_226440784.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KI612_RS14530 (KI612_14585) 3044761..3045066 + 306 WP_226440785.1 HigA family addiction module antitoxin Antitoxin
KI612_RS14535 (KI612_14590) 3045076..3045528 + 453 WP_226440786.1 MaoC family dehydratase -
KI612_RS14540 (KI612_14595) 3045660..3047519 + 1860 WP_226440787.1 potassium transporter Kup -
KI612_RS14545 (KI612_14600) 3047665..3048297 + 633 WP_226440788.1 AbiV family abortive infection protein -
KI612_RS14550 (KI612_14605) 3048394..3049614 - 1221 WP_226440789.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(6-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10865.18 Da        Isoelectric Point: 7.8620

>T203365 WP_226440784.1 NZ_CP075188:3044470-3044751 [Quatrionicoccus australiensis]
MTIRSFRCTETEALYAGESSRRFRNIESVAQRKLQMQDAAAELRDLRAPPGNRLEALSDDRAGQHSIRINEQWRICFKWT
ENGPTRVEIVDYH

Download         Length: 282 bp

>T203365 NZ_CP099973:c3987812-3987525 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGCTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCTCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11485.19 Da        Isoelectric Point: 5.7135

>AT203365 WP_226440785.1 NZ_CP075188:3044761-3045066 [Quatrionicoccus australiensis]
MATNNMRAIHPGEILREEFLLPLDMSANALAMALHVPAPRINDIVREKRAISPDTALRLARYFDTTALFWLNLQSTFDLK
QAENENAERIAEEVRPLQRAA

Download         Length: 306 bp

>AT203365 NZ_CP099973:c3987538-3987236 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAGCATGGTTAAACATAAACGCGGCAATGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References