Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2817209..2817831 Replicon chromosome
Accession NZ_CP075183
Organism Hydrogenophaga taeniospiralis strain LT2

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag KI616_RS13885 Protein ID WP_226466943.1
Coordinates 2817209..2817478 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KI616_RS13890 Protein ID WP_226466944.1
Coordinates 2817526..2817831 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI616_RS13860 (KI616_13820) 2812635..2813051 + 417 WP_226466940.1 hypothetical protein -
KI616_RS13865 (KI616_13825) 2813107..2813739 + 633 WP_226466941.1 DOMON-like domain-containing protein -
KI616_RS13870 (KI616_13830) 2813749..2814951 + 1203 WP_226466942.1 DUF1343 domain-containing protein -
KI616_RS13875 (KI616_13835) 2814967..2815455 - 489 WP_226467045.1 GNAT family N-acetyltransferase -
KI616_RS13880 (KI616_13840) 2815455..2816789 - 1335 WP_177133940.1 phosphoglucosamine mutase -
KI616_RS13885 (KI616_13845) 2817209..2817478 + 270 WP_226466943.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KI616_RS13890 (KI616_13850) 2817526..2817831 + 306 WP_226466944.1 HigA family addiction module antitoxin Antitoxin
KI616_RS13895 (KI616_13855) 2817942..2819432 - 1491 WP_226466945.1 sugar ABC transporter ATP-binding protein -
KI616_RS13900 (KI616_13860) 2819445..2820527 - 1083 WP_226466946.1 strictosidine synthase -
KI616_RS13905 (KI616_13865) 2820531..2822648 - 2118 WP_226466947.1 SMP-30/gluconolactonase/LRE family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(8-89)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-92)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10122.48 Da        Isoelectric Point: 6.4444

>T203358 WP_226466943.1 NZ_CP075183:2817209-2817478 [Hydrogenophaga taeniospiralis]
MSIQSFACSDTESLFTTGKCRRFVNIKSVAERKLAQLDAAPSVCFMKAPPGNDLKEYDGAWHVRINDQWRLTFKWGESGP
YDVLIEDPH

Download         Length: 270 bp

>T203358 NZ_CP099973:825272-825685 [Salmonella enterica subsp. enterica serovar Enteritidis]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11191.02 Da        Isoelectric Point: 8.4666

>AT203358 WP_226466944.1 NZ_CP075183:2817526-2817831 [Hydrogenophaga taeniospiralis]
MFKNGMRPVHPGEILLEDYIKPMGVSVRAVAMALHVPYSRLSEITKGERGVSADTALRLERYFGSEAKGWLNLQAAYELR
MAEIENGKAIAKEIQPFALAA

Download         Length: 306 bp

>AT203358 NZ_CP099973:825025-825291 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGACGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References