203356

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5778803..5779398 Replicon chromosome
Accession NZ_CP075176
Organism Pseudomonas aeruginosa strain PA790

Toxin (Protein)


Gene name higB Uniprot ID A0A9E8L6K5
Locus tag KIK44_RS27375 Protein ID WP_071534386.1
Coordinates 5779120..5779398 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KIK44_RS27370 Protein ID WP_003133769.1
Coordinates 5778803..5779108 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KIK44_RS27355 (KIK44_27355) 5774591..5775265 - 675 WP_079381483.1 DUF2290 domain-containing protein -
KIK44_RS27360 (KIK44_27360) 5775262..5777469 - 2208 WP_079381482.1 ATP-binding domain-containing protein -
KIK44_RS27365 (KIK44_27365) 5777877..5778467 - 591 WP_108703096.1 ankyrin repeat domain-containing protein -
KIK44_RS27370 (KIK44_27370) 5778803..5779108 - 306 WP_003133769.1 HigA family addiction module antitoxin Antitoxin
KIK44_RS27375 (KIK44_27375) 5779120..5779398 - 279 WP_071534386.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KIK44_RS32810 5779451..5779573 - 123 Protein_5421 integrase -
KIK44_RS27380 (KIK44_27380) 5779721..5781949 + 2229 WP_033938414.1 TonB-dependent receptor -
KIK44_RS27385 (KIK44_27385) 5782019..5782666 - 648 WP_003095021.1 carbonate dehydratase -
KIK44_RS27390 (KIK44_27390) 5782728..5783966 - 1239 WP_033938412.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10698.23 Da        Isoelectric Point: 7.9184

>T203356 WP_071534386.1 NZ_CP075176:c5779398-5779120 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMHHAATELRDLRSPPGNRLEPLQGKRVGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T203356 NZ_CP099973:310524-310892 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGTCGTTCGCTTACGCGCCTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11214.73 Da        Isoelectric Point: 4.6081

>AT203356 WP_003133769.1 NZ_CP075176:c5779108-5778803 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG

Download         Length: 306 bp

>AT203356 NZ_CP099973:310306-310527 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGCGCGGTGACGGCGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References