Detailed information of TA system TA203343

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1966056..1966618
• Replicon: chromosome
• Accession: NZ_CP075174
• Organism: Salmonella enterica subsp. houtenae serovar 45:gz51:- strain 20-369

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A727YRU0
• Locus tag: KI721_RS09445
• Protein ID: WP_000597305.1
• Coordinates: 1966340..1966618 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: KI721_RS09440
• Protein ID: WP_079812445.1
• Coordinates: 1966056..1966340 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KI721_RS09405 (1961396)	1961396..1962052	-	657	WP_079812453.1	carbon-nitrogen hydrolase family protein	-
KI721_RS09410 (1962159)	1962159..1962389	-	231	WP_000856224.1	DNA polymerase III subunit theta	-
KI721_RS09415 (1962527)	1962527..1962901	+	375	WP_001664129.1	CopC domain-containing protein YobA	-
KI721_RS09420 (1962902)	1962902..1963777	+	876	WP_079812452.1	copper homeostasis membrane protein CopD	-
KI721_RS09425 (1963794)	1963794..1964144	+	351	WP_000746717.1	YebY family protein	-
KI721_RS09430 (1964511)	1964511..1964906	-	396	Protein_1840	tyrosine-type recombinase/integrase	-
KI721_RS09435 (1965181)	1965181..1965897	+	717	WP_233679877.1	T3SS effector NleG family protein	-
KI721_RS09440 (1966056)	1966056..1966340	-	285	WP_079812445.1	HigA family addiction module antitoxin	Antitoxin
KI721_RS09445 (1966340)	1966340..1966618	-	279	WP_000597305.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KI721_RS09450 (1966870)	1966870..1967130	+	261	WP_079812444.1	hypothetical protein	-
KI721_RS09455 (1967201)	1967201..1967884	-	684	WP_079812443.1	PipA/GogA/GtgA family type III secretion system effector	-
KI721_RS09460 (1968309)	1968309..1968995	+	687	WP_233679878.1	hypothetical protein	-
KI721_RS09465 (1969142)	1969142..1969673	+	532	Protein_1847	tail fiber assembly protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1932493..1969576	37083

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (3-92)

Antitoxin

• Cro/C1-type helix-turn-helix domain (10-65)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10737.17 Da
• Isoelectric Point: 8.4694

>T203343 WP_000597305.1 NZ_CP075174:c1966618-1966340 [Salmonella enterica subsp. houtenae serovar 45:g,z51:-]
MIKSFRHKGLNKFYQKGDSSGLEQSLVPRLKNRLSMLDAAKTIDFLNQQGYDLHELKGDRAETWSIKVSGNWRLTFIFEN
GDVYVLNLEDYH

Nucleotide

• Length: 279 bp

>T203343 NZ_CP099914:3391576-3391794 [Escherichia albertii]
ATGTCCGATAAACCTTTAACAAAAACCGATTATTTGATGCGTCTGCGTCGTTGCCAGACAATTGACACACTGGAACGTGT
TATCGAGAAAAATAAATATGAATTATCAGATAATGAATTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTTGCAGAGC
TGACTATGAATAAGCTATATGACAAGATCCCTTCCTCAGTGTGGAAATTCATTCGGTAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10214.76 Da
• Isoelectric Point: 5.6051

>AT203343 WP_079812445.1 NZ_CP075174:c1966340-1966056 [Salmonella enterica subsp. houtenae serovar 45:g,z51:-]
MAMFDPAYPGEIIAEILEDQGVSLRQFAVAMNIAPSTASRILNGKVSITPEMAVKLAIVLGGDAESWLNLQNNYSLSQAR
KTVDITHVHRLSFA

Nucleotide

• Length: 285 bp

>AT203343 NZ_CP099914:3391176-3391550 [Escherichia albertii]
ATGGATGAATACTCACCAAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGTAACCATGGCTGGGTAAATGACCCAACCTCGGCAATCAATCTACAGCTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAACAGATTGATGAATATCTG
GACGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAACCGATT
GTTCCGTTGCTTTGTTAACGCCACCAAAGCGAATCCTGCAAGTTTATCTTGTTAG

Structures

Toxin

• AlphaFold DB: A0A727YRU0