Detailed information of TA system TA203333

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 1795218..1795878
• Replicon: chromosome
• Accession: NZ_CP075174
• Organism: Salmonella enterica subsp. houtenae serovar 45:gz51:- strain 20-369

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: KI721_RS08525
• Protein ID: WP_079807796.1
• Coordinates: 1795218..1795571 (+)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: KI721_RS08530
• Protein ID: WP_000533828.1
• Coordinates: 1795576..1795878 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KI721_RS08510 (1790916)	1790916..1793807	+	2892	WP_233679872.1	RHS repeat domain-containing protein	-
KI721_RS08515 (1794180)	1794180..1794502	+	323	Protein_1667	hypothetical protein	-
KI721_RS08520 (1794499)	1794499..1794720	+	222	WP_079800261.1	helix-turn-helix transcriptional regulator	-
KI721_RS08525 (1795218)	1795218..1795571	+	354	WP_079807796.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KI721_RS08530 (1795576)	1795576..1795878	+	303	WP_000533828.1	XRE family transcriptional regulator	Antitoxin
KI721_RS08535 (1796383)	1796383..1796586	+	204	Protein_1671	DNA-binding protein	-
KI721_RS08540 (1797236)	1797236..1798498	-	1263	WP_134953895.1	integrase arm-type DNA-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (33-81)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 13472.39 Da
• Isoelectric Point: 9.0134

>T203333 WP_079807796.1 NZ_CP075174:1795218-1795571 [Salmonella enterica subsp. houtenae serovar 45:g,z51:-]
VWTIKTTDMFDHWFSSLNDTDRASVLAALLVLREKGPGLSRPYADTLRGSRFSNMKELRIQSRGDPIRAFFAFDPTRTGI
VLCAGNKVGNEKRFYDEMLPVADREFTNWLNIIKEKE

Nucleotide

• Length: 354 bp

>T203333 NZ_CP099914:305278-305805 [Escherichia albertii]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTTTGCGAGCGTATATCCTTTGCCGCAACACTC
CAGAACGTCAGGTCCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTCACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCATTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCTCTGAATGAAAAAGCCCATACGTTTTATCAGTCGCTGGGCTTTATCCCGTTGGTTGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATTGAACTGCTTTTTACACAGAGCGATTAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11100.93 Da
• Isoelectric Point: 5.7316

>AT203333 WP_000533828.1 NZ_CP075174:1795576-1795878 [Salmonella enterica subsp. houtenae serovar 45:g,z51:-]
MGRTLEQLIADEKPEVVAEAQAMATDILLNIHLAELREKVQKTQVEMAQMLGIRQPTVAGMEKPGRDLKLSTLKRYVEAT
GGKLRLDVELPDGSHYGFVL

Nucleotide

• Length: 303 bp

>AT203333 NZ_CP099914:305005-305271 [Escherichia albertii]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAATCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGAGCTGCGGAAGTGATTGAACAGCATCGGCGGA
TGATTCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGTTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA