Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1915419..1915957 Replicon chromosome
Accession NZ_CP075169
Organism Sodalis ligni strain dw23

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GTU79_RS08995 Protein ID WP_275956924.1
Coordinates 1915706..1915957 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag GTU79_RS08990 Protein ID WP_132922530.1
Coordinates 1915419..1915706 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTU79_RS08955 (GTU79_08955) 1910725..1910949 - 225 WP_214513854.1 DUF2594 family protein -
GTU79_RS08960 (GTU79_08960) 1911593..1912249 + 657 WP_203522154.1 UvrY/SirA/GacA family response regulator transcription factor -
GTU79_RS08965 (GTU79_08965) 1912242..1914071 + 1830 Protein_1752 excinuclease ABC subunit UvrC -
GTU79_RS08970 (GTU79_08970) 1914130..1914678 + 549 WP_132922572.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
GTU79_RS08990 (GTU79_08990) 1915419..1915706 - 288 WP_132922530.1 HigA family addiction module antitoxin Antitoxin
GTU79_RS08995 (GTU79_08995) 1915706..1915957 - 252 WP_275956924.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GTU79_RS09000 (GTU79_09000) 1916483..1916875 - 393 WP_214513855.1 DUF2442 domain-containing protein -
GTU79_RS09005 (GTU79_09005) 1916865..1917068 - 204 WP_207917827.1 DUF4160 domain-containing protein -
GTU79_RS09010 (GTU79_09010) 1917491..1917621 - 131 Protein_1758 transcriptional regulator -
GTU79_RS09015 (GTU79_09015) 1917759..1918592 - 834 WP_203522152.1 metal ABC transporter permease -
GTU79_RS09020 (GTU79_09020) 1918574..1919458 - 885 WP_203522151.1 metal ABC transporter permease -
GTU79_RS09025 (GTU79_09025) 1919465..1920298 - 834 WP_214513856.1 metal ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-83)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-67)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9499.70 Da        Isoelectric Point: 6.4625

>T203304 WP_275956924.1 NZ_CP075169:c1915957-1915706 [Sodalis ligni]
MRLFFEKGSTAGIDAKQSGKLRLRLAVLDAAEEIKDIDRPGYSLHTLTGDRKGQWSITVTGNWRITFEFMDGNAYIVNYE
DYH

Download         Length: 252 bp

>T203304 NZ_CP099910:1962566-1962898 [Escherichia albertii]
ATGGACAGAGGAGAAATCTGGCTTGTTTCACTTGACCCTATCGCCGGGCATGAGCAAAGCGGAAAACGCCCGGTGCTTAT
CGTTTCTCCGGCCTCGTTTAACGAGGTCACCCGGTTGCCCGTCATTGTTCCGGTAACCAGCGGTGGGCAATTTGCCCGTA
GCGCGGGTTTTGCGGTTTCGCTGGAGGGCGCTGGCACAAAAACGACGGGGATTATTCGTTGCGATCAGCCCAGAACCATT
GATATGGGAGCCCGAAACGGTAAGCGGCTGGAGCGCATACCTGACGGTATCATCAACGAGGTGCTGGCAAGGCTGGAAAC
CATCCTGGCCTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10373.98 Da        Isoelectric Point: 6.8779

>AT203304 WP_132922530.1 NZ_CP075169:c1915706-1915419 [Sodalis ligni]
MTMFNPPHPGEIIAETLDDLNIGIRELSRALHVAPSTVQRLVSGHSAVSPEMALKLSAVLGSSAKFWLNLQDNYSLWAAQ
KEVDISKLHRLVAVA

Download         Length: 288 bp

>AT203304 NZ_CP099910:1962308-1962565 [Escherichia albertii]
ATGTATACCACACGTCTGAAAAAGGTTGGCGGTTCTGTCATGCTGGCTGTTCCGCCCGCCGTGCTGAAAACGCTGGCCCT
GTTGCCGGACAGCGAAGTCGGTGTAACCATCGACAACGGCTGCCTGATTATCGAACCGCAAAAACGACCACGCTATTCAC
TGGCCGAACTGCTGGCGCAATGCGATCCCCATGAAGAAATCAGTGATGAGGAGCGCGAATGGATTGATGCGCCTGCCGCA
GGGAAGGAGATCCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References