Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 748566..749146 Replicon chromosome
Accession NZ_CP075169
Organism Sodalis ligni strain dw23

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GTU79_RS03495 Protein ID WP_203522871.1
Coordinates 748566..748847 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GTU79_RS03500 Protein ID WP_132923503.1
Coordinates 748859..749146 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTU79_RS03470 (GTU79_03470) 743998..744411 + 414 WP_203522874.1 RcnB family protein -
GTU79_RS03475 (GTU79_03475) 744635..745057 + 423 WP_132923507.1 DUF3830 family protein -
GTU79_RS03480 (GTU79_03480) 745057..745602 + 546 WP_203522873.1 hypothetical protein -
GTU79_RS03485 (GTU79_03485) 745846..746760 + 915 WP_203522872.1 MurR/RpiR family transcriptional regulator -
GTU79_RS03490 (GTU79_03490) 746880..748430 + 1551 WP_253073484.1 histidine ammonia-lyase -
GTU79_RS03495 (GTU79_03495) 748566..748847 + 282 WP_203522871.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GTU79_RS03500 (GTU79_03500) 748859..749146 + 288 WP_132923503.1 HigA family addiction module antitoxin Antitoxin
GTU79_RS03505 (GTU79_03505) 749444..750163 + 720 WP_203522870.1 ABC transporter permease subunit -
GTU79_RS03510 (GTU79_03510) 750160..750891 + 732 WP_275956915.1 ABC transporter permease -
GTU79_RS03515 (GTU79_03515) 750938..751795 + 858 WP_203522869.1 transporter substrate-binding domain-containing protein -
GTU79_RS03520 (GTU79_03520) 751925..754012 + 2088 WP_203522868.1 hydantoinase/oxoprolinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-63)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10432.89 Da        Isoelectric Point: 10.1387

>T203300 WP_203522871.1 NZ_CP075169:748566-748847 [Sodalis ligni]
MIKSFKHKGMERFYKTGSAAGIQTAHTSRLRGQLFALSKAKKPCDMGAPGWNLHPLKGNEAGVWSVSVNGDWRMTFRFDA
DGDAVLVDYRDYH

Download         Length: 282 bp

>T203300 NZ_CP099910:167539-167691 [Escherichia albertii]
ATGCCGCAGAAATATAGATTGCTTTCTTTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGATAAGGGATTC
ACTGTGTGAATTGCATATTAAACAGGGGAGTTATGAGCTGGCGGCGTTTTTAGCCTGCAATTTGAAAGAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10670.27 Da        Isoelectric Point: 6.9884

>AT203300 WP_132923503.1 NZ_CP075169:748859-749146 [Sodalis ligni]
MRMFNPPHPGEVLRDYLEGVSVTDAAASLKITRTQLSRILNAHAAITADMALRLSSLLGTSAEMWVDMQSEYELWQAAQR
PRPVIEPLHRPHVHA

Download         Length: 288 bp

>AT203300 NZ_CP099910:c167488-167434 [Escherichia albertii]
GTTCAGGCATAGGGTAGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References