Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HTH(antitoxin) |
Location | 4657978..4658580 | Replicon | chromosome |
Accession | NZ_CP075141 | ||
Organism | Salmonella enterica strain CFSAN033950 |
Toxin (Protein)
Gene name | higB | Uniprot ID | C0Q3J8 |
Locus tag | ACV97_RS22660 | Protein ID | WP_001159630.1 |
Coordinates | 4658269..4658580 (-) | Length | 104 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | ACV97_RS22655 | Protein ID | WP_000362050.1 |
Coordinates | 4657978..4658268 (-) | Length | 97 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
ACV97_RS22640 (4655471) | 4655471..4656373 | + | 903 | WP_000331361.1 | formate dehydrogenase subunit beta | - |
ACV97_RS22645 (4656370) | 4656370..4657005 | + | 636 | WP_000829025.1 | formate dehydrogenase cytochrome b556 subunit | - |
ACV97_RS22650 (4657002) | 4657002..4657931 | + | 930 | WP_000027730.1 | formate dehydrogenase accessory protein FdhE | - |
ACV97_RS22655 (4657978) | 4657978..4658268 | - | 291 | WP_000362050.1 | DNA-binding transcriptional regulator | Antitoxin |
ACV97_RS22660 (4658269) | 4658269..4658580 | - | 312 | WP_001159630.1 | cytotoxic translational repressor of toxin-antitoxin stability system | Toxin |
ACV97_RS22665 (4658798) | 4658798..4659727 | + | 930 | WP_001127703.1 | alpha/beta hydrolase | - |
ACV97_RS22670 (4659813) | 4659813..4660124 | + | 312 | WP_000558166.1 | type II toxin-antitoxin system HigB family toxin | - |
ACV97_RS22675 (4660121) | 4660121..4660567 | + | 447 | WP_001259011.1 | type II toxin-antitoxin system HigA family antitoxin | - |
ACV97_RS22680 (4660582) | 4660582..4661523 | - | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
ACV97_RS22685 (4661568) | 4661568..4662005 | - | 438 | WP_000560974.1 | D-aminoacyl-tRNA deacylase | - |
ACV97_RS22690 (4662002) | 4662002..4662874 | - | 873 | WP_000921427.1 | virulence factor BrkB family protein | - |
ACV97_RS22695 (4662868) | 4662868..4663467 | - | 600 | WP_000965695.1 | glucose-1-phosphatase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12326.27 Da Isoelectric Point: 9.4460
>T203294 WP_001159630.1 NZ_CP075141:c4658580-4658269 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW
Download Length: 312 bp
>T203294 NZ_CP099907:4018849-4019001 [Escherichia albertii]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA
Antitoxin
Download Length: 97 a.a. Molecular weight: 10971.59 Da Isoelectric Point: 10.6525
>AT203294 WP_000362050.1 NZ_CP075141:c4658268-4657978 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY
Download Length: 291 bp
>AT203294 NZ_CP099907:c4018800-4018743 [Escherichia albertii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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