Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4657978..4658580 Replicon chromosome
Accession NZ_CP075141
Organism Salmonella enterica strain CFSAN033950

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag ACV97_RS22660 Protein ID WP_001159630.1
Coordinates 4658269..4658580 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ACV97_RS22655 Protein ID WP_000362050.1
Coordinates 4657978..4658268 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACV97_RS22640 (4655471) 4655471..4656373 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
ACV97_RS22645 (4656370) 4656370..4657005 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
ACV97_RS22650 (4657002) 4657002..4657931 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
ACV97_RS22655 (4657978) 4657978..4658268 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
ACV97_RS22660 (4658269) 4658269..4658580 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
ACV97_RS22665 (4658798) 4658798..4659727 + 930 WP_001127703.1 alpha/beta hydrolase -
ACV97_RS22670 (4659813) 4659813..4660124 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
ACV97_RS22675 (4660121) 4660121..4660567 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
ACV97_RS22680 (4660582) 4660582..4661523 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
ACV97_RS22685 (4661568) 4661568..4662005 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
ACV97_RS22690 (4662002) 4662002..4662874 - 873 WP_000921427.1 virulence factor BrkB family protein -
ACV97_RS22695 (4662868) 4662868..4663467 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T203294 WP_001159630.1 NZ_CP075141:c4658580-4658269 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

>T203294 NZ_CP099907:4018849-4019001 [Escherichia albertii]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT203294 WP_000362050.1 NZ_CP075141:c4658268-4657978 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp

>AT203294 NZ_CP099907:c4018800-4018743 [Escherichia albertii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References