203290

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2374865..2375387 Replicon chromosome
Accession NZ_CP075141
Organism Salmonella enterica strain CFSAN033950

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag ACV97_RS11475 Protein ID WP_000221343.1
Coordinates 2375103..2375387 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag ACV97_RS11470 Protein ID WP_000885424.1
Coordinates 2374865..2375113 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACV97_RS11445 (2370081) 2370081..2371547 + 1467 WP_000987828.1 hypothetical protein -
ACV97_RS11450 (2372355) 2372355..2373069 + 715 Protein_2244 helix-turn-helix domain-containing protein -
ACV97_RS11455 (2373125) 2373125..2374033 - 909 WP_010989018.1 hypothetical protein -
ACV97_RS11460 (2374176) 2374176..2374508 - 333 WP_064239733.1 DUF1493 family protein -
ACV97_RS11465 (2374498) 2374498..2374713 - 216 WP_000206207.1 hypothetical protein -
ACV97_RS11470 (2374865) 2374865..2375113 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ACV97_RS11475 (2375103) 2375103..2375387 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ACV97_RS11480 (2375558) 2375558..2375947 + 390 WP_000194089.1 RidA family protein -
ACV97_RS11485 (2375999) 2375999..2377078 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
ACV97_RS11490 (2377271) 2377271..2377759 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
ACV97_RS11495 (2377804) 2377804..2379312 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2370084..2382169 12085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T203290 WP_000221343.1 NZ_CP075141:2375103-2375387 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T203290 NZ_CP099907:2519180-2519458 [Escherichia albertii]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCAAGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ACCCATTAAGCGGCGATCGCGATGGCATCTGGGCAATATCTGTATCAGGCAACTGGCGAATCACGTTTGAGTTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT203290 WP_000885424.1 NZ_CP075141:2374865-2375113 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT203290 NZ_CP099907:2519458-2519742 [Escherichia albertii]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTGAACGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGACTGTTGACCGGAAAAGCGGCTTTGACGCCAGAAATGGCGA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCTGAG
AAAACGGTGGATGTGTCGCGGTTGCGCCGTCTGGTTGCGCAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References