Detailed information of TA system TA203288

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2218258..2218483
• Replicon: chromosome
• Accession: NZ_CP075141
• Organism: Salmonella enterica strain CFSAN033950

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: ACV97_RS10715
• Protein ID: WP_000813254.1
• Coordinates: 2218328..2218483 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2218258..2218316 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ACV97_RS10670	2213704..2213979	+	276	WP_063916787.1	YdaS family helix-turn-helix protein	-
ACV97_RS10675	2213963..2214385	+	423	WP_031571023.1	toxin YdaT family protein	-
ACV97_RS10680	2214405..2214818	+	414	WP_074177122.1	hypothetical protein	-
ACV97_RS10685	2215147..2215935	+	789	WP_063916784.1	hypothetical protein	-
ACV97_RS10690	2215942..2216688	+	747	WP_063916783.1	ATP-binding protein	-
ACV97_RS10695	2216719..2217111	+	393	WP_064239761.1	DUF977 family protein	-
ACV97_RS10700	2217268..2217450	+	183	WP_001224672.1	hypothetical protein	-
ACV97_RS10705	2217443..2217619	+	177	WP_188317577.1	hypothetical protein	-
ACV97_RS10710	2217641..2218036	+	396	WP_074379258.1	hypothetical protein	-
-	2218258..2218316	-	59	-	-	Antitoxin
ACV97_RS10715	2218328..2218483	+	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
ACV97_RS10720	2218774..2218944	+	171	WP_000734094.1	hypothetical protein	-
ACV97_RS10725	2219007..2219606	+	600	WP_000940751.1	DUF1367 family protein	-
ACV97_RS10730	2219606..2219896	+	291	WP_000774470.1	DUF1364 domain-containing protein	-
ACV97_RS10735	2219893..2220442	+	550	Protein_2101	DUF1133 family protein	-
ACV97_RS10740	2222595..2223020	+	426	WP_050161598.1	TerB family tellurite resistance protein	-
ACV97_RS10745	2223017..2223169	+	153	WP_064485345.1	DUF3927 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2201424..2229459	28035

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T203288 WP_000813254.1 NZ_CP075141:2218328-2218483 [Salmonella enterica]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T203288 NZ_CP099907:2428369-2428656 [Escherichia albertii]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin

Nucleotide

• Length: 59 bp

>AT203288 NZ_CP075141:c2218316-2218258 [Salmonella enterica]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin