Detailed information of TA system TA203284

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 2207291..2207652
• Replicon: chromosome
• Accession: NZ_CP075141
• Organism: Salmonella enterica strain CFSAN033950

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: A0A8E7W0U7
• Locus tag: ACV97_RS10625
• Protein ID: WP_074177123.1
• Coordinates: 2207458..2207652 (-)
• Length: 65 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	2207291..2207459 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ACV97_RS10600 (2203320)	2203320..2204693	+	1374	WP_000206674.1	ATP-dependent RNA helicase DbpA	-
ACV97_RS10605 (2204737)	2204737..2205672	-	936	WP_001156208.1	tRNA 2-thiocytidine(32) synthetase TtcA	-
ACV97_RS10610 (2205724)	2205724..2206959	-	1236	WP_063916792.1	site-specific integrase	-
ACV97_RS10615 (2206961)	2206961..2207176	-	216	WP_000079604.1	excisionase XisR	-
- (2207291)	2207291..2207459	+	169	NuclAT_0	-	Antitoxin
- (2207291)	2207291..2207459	+	169	NuclAT_0	-	Antitoxin
- (2207291)	2207291..2207459	+	169	NuclAT_0	-	Antitoxin
- (2207291)	2207291..2207459	+	169	NuclAT_0	-	Antitoxin
ACV97_RS10620 (2207277)	2207277..2207465	-	189	WP_058108251.1	DUF1187 family protein	-
ACV97_RS10625 (2207458)	2207458..2207652	-	195	WP_074177123.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
ACV97_RS10630 (2207699)	2207699..2208379	-	681	WP_064239763.1	YqaJ viral recombinase family protein	-
ACV97_RS10635 (2208376)	2208376..2209161	-	786	WP_064239762.1	phage recombination protein Bet	-
ACV97_RS10640 (2209167)	2209167..2209463	-	297	WP_044128337.1	host-nuclease inhibitor Gam family protein	-
ACV97_RS10645 (2209682)	2209682..2211184	-	1503	Protein_2083	exonuclease VIII	-
ACV97_RS10650 (2211212)	2211212..2211529	-	318	WP_000800272.1	hypothetical protein	-
ACV97_RS10655 (2211614)	2211614..2211835	-	222	WP_000560208.1	cell division protein FtsZ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2201424..2229459	28035

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-54)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7107.08 Da
• Isoelectric Point: 8.6419

>T203284 WP_074177123.1 NZ_CP075141:c2207652-2207458 [Salmonella enterica]
MRYDDVKPCPFCGCPAVTVKAISGYFRVKCDGCESRSGYGGSQKEALVRWNKRATENINGSYHV

Nucleotide

• Length: 195 bp

>T203284 NZ_CP099907:889827-890231 [Escherichia albertii]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTCTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGCTATTTTACTCATGCCCTGGCCGCTAAGTTATACCCCGTTATGGATGGTGTTGCTTTCGCTGGTGGTGTTTGATTGCG
TCCGCAGTCAGCGGCGCATTAATGCTCGTCAGGGGGAGATTCGCCTGTTGATGGATGGGCGTTTACGCTGGCAGGGGCAG
GAGTGGAGCATCGTCAGAGCGCCGTGGATGATTAAAACTGGCATGATGTTGCGTTTACTCTCTGATAGCGGCAAACGTCA
GCACCTGTGGCTGGCAGCCGACAGTATGGATGAAGCTGAATGGCGGGATTTGCGGCGAATTTTGTTACAACAAGAGATAC
AGTGA

Antitoxin

Nucleotide

• Length: 169 bp

>AT203284 NZ_CP075141:2207291-2207459 [Salmonella enterica]
GTTTCTTGCAATTAAAATTAACCAGTTTTACTTTTTGTTTGCGGGAAACCCCGGCCTCGGTTTTTCCTGAGAGCATTTTT
TCGCATTCTGATTTGGTTAGTTTAGTTTTTGAGTATCTTGTCCAGTTGGTAGGCAAACCGCCTTCCTTTTCAATTGTGGC
GGTAATTTT

Structures

Antitoxin