Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 1894190..1894817 Replicon chromosome
Accession NZ_CP075138
Organism Salmonella enterica strain CFSAN044875

Toxin (Protein)


Gene name higB Uniprot ID A0A5Y2FSH1
Locus tag A7R97_RS24505 Protein ID WP_024131287.1
Coordinates 1894488..1894817 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag A7R97_RS24500 Protein ID WP_000147078.1
Coordinates 1894190..1894498 (-) Length 103 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7R97_RS09055 (1889447) 1889447..1890274 - 828 WP_053299710.1 DUF2303 family protein -
A7R97_RS09060 (1890332) 1890332..1890703 - 372 WP_000997190.1 hypothetical protein -
A7R97_RS09065 (1891403) 1891403..1891678 - 276 WP_001514782.1 hypothetical protein -
A7R97_RS09070 (1891680) 1891680..1891931 - 252 WP_001574551.1 hypothetical protein -
A7R97_RS09075 (1891859) 1891859..1892044 - 186 WP_070794471.1 ClpX C4-type zinc finger protein -
A7R97_RS09080 (1892249) 1892249..1892944 - 696 WP_053299709.1 helix-turn-helix transcriptional regulator -
A7R97_RS09085 (1893042) 1893042..1893266 + 225 WP_001191666.1 helix-turn-helix transcriptional regulator -
A7R97_RS09090 (1893295) 1893295..1893849 + 555 WP_000509731.1 YmfL family putative regulatory protein -
A7R97_RS24495 (1893995) 1893995..1894171 + 177 WP_000281065.1 DUF4222 domain-containing protein -
A7R97_RS24500 (1894190) 1894190..1894498 - 309 WP_000147078.1 helix-turn-helix transcriptional regulator Antitoxin
A7R97_RS24505 (1894488) 1894488..1894817 - 330 WP_024131287.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A7R97_RS24510 (1894731) 1894731..1895696 + 966 WP_223196747.1 Rha family phage regulatory protein -
A7R97_RS09100 (1895693) 1895693..1895917 + 225 WP_000620702.1 hypothetical protein -
A7R97_RS09105 (1895914) 1895914..1896888 + 975 WP_000096529.1 conserved phage C-terminal domain-containing protein -
A7R97_RS09110 (1896885) 1896885..1897358 + 474 WP_000054227.1 PerC family transcriptional regulator -
A7R97_RS09115 (1897355) 1897355..1898236 + 882 WP_000200166.1 Dam family site-specific DNA-(adenine-N6)-methyltransferase -
A7R97_RS09120 (1898245) 1898245..1898634 + 390 WP_000779149.1 RusA family crossover junction endodeoxyribonuclease -
A7R97_RS09125 (1898651) 1898651..1899511 + 861 WP_001061452.1 KilA-N domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(16-103)

Antitoxin

(44-94)


Sequences


Toxin        


Download         Length: 110 a.a.        Molecular weight: 12781.80 Da        Isoelectric Point: 9.8238

>T203239 WP_024131287.1 NZ_CP075138:c1894817-1894488 [Salmonella enterica]
MNYTIEYYNEEVRIEVDQLPLSMRARYQHLVERMKVYGSNLGEPHTSAFGDGLFELRIKGSDGIARVFYCTLAGKRIVML
HSFIKKTQKTPVAERKKAETRMKEVKHDW

Download         Length: 330 bp

>T203239 NZ_CP099898:2385495-2385773 [Escherichia albertii]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCTGCAAGCAGTCTTGTTGATATCGATATGCCCGGTTACCGACTAC
ACCCATTAAGCGGCGATCGCGATGGCATCTGGGCAATATCTGTATCAGGCAACTGGCGAATCACGTTTGAGTTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11110.77 Da        Isoelectric Point: 7.0152

>AT203239 WP_000147078.1 NZ_CP075138:c1894498-1894190 [Salmonella enterica]
MTGKRNAPTITHDEMAAKWMEDPAFKAEYDAIADEFALLDEMLAARKEAGLTQAEVAERMGTKATAITRMESNLAAGVSG
PSFTTLKKFAQATGKKLQIRFV

Download         Length: 309 bp

>AT203239 NZ_CP099898:2385773-2386057 [Escherichia albertii]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTGAACGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGACTGTTGACCGGAAAAGCGGCTTTGACGCCAGAAATGGCGA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCTGAG
AAAACGGTGGATGTGTCGCGGTTGCGCCGTCTGGTTGCGCAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A5Y2FSH1


Antitoxin

Source ID Structure

References