Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 360310..360848 Replicon chromosome
Accession NZ_CP075138
Organism Salmonella enterica strain CFSAN044875

Toxin (Protein)


Gene name yafQ Uniprot ID A0A486WWL6
Locus tag A7R97_RS01630 Protein ID WP_001626961.1
Coordinates 360573..360848 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A7U1KUN1
Locus tag A7R97_RS01625 Protein ID WP_000729714.1
Coordinates 360310..360570 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7R97_RS01610 (356063) 356063..357616 + 1554 WP_023227917.1 TROVE domain-containing protein -
A7R97_RS01615 (357964) 357964..359178 + 1215 WP_070793431.1 RNA-splicing ligase RtcB -
A7R97_RS01620 (359182) 359182..360201 + 1020 WP_000101027.1 RNA 3'-terminal phosphate cyclase -
A7R97_RS01625 (360310) 360310..360570 + 261 WP_000729714.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
A7R97_RS01630 (360573) 360573..360848 + 276 WP_001626961.1 type II toxin-antitoxin system YafQ family toxin Toxin
A7R97_RS01635 (360936) 360936..363641 - 2706 WP_000907030.1 HTH-type transcriptional regulator MalT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10619.19 Da        Isoelectric Point: 8.9063

>T203236 WP_001626961.1 NZ_CP075138:360573-360848 [Salmonella enterica]
MGQREIEYSGQFQKDVKRAQKRHKDVGKLKTLMTLLIHHPFPLPAIYKDHPLQGSYSGYRDAHIGPDWILIDKITDECLR
FERTGTHADLF

Download         Length: 276 bp

>T203236 NZ_CP099898:1048040-1048192 [Escherichia albertii]
ATGCTGACAAAATATGCCCTTGTGGCAATCATCGTACTGTGTTGTACAGTACTGGGATTCACGCTGATGGTAGGCGACTC
GTTGTGTGAGTTGAGTATCAGAGAACGTGGTATGGAGTTTAAGGCAGTTCTCGCTTACGAATCGAAGAAGTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9445.82 Da        Isoelectric Point: 4.6028

>AT203236 WP_000729714.1 NZ_CP075138:360310-360570 [Salmonella enterica]
MAANALVRARIDETLKNQAADVLAEMGLTISDLIRITLTKVAREKALPFDLRIPNELTSRTIENSEAGVDIHKAKDADDL
FDQLGI

Download         Length: 261 bp

>AT203236 NZ_CP099898:c1047995-1047947 [Escherichia albertii]
GTTCGAACGTAGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486WWL6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U1KUN1

References