Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4685147..4685901 Replicon chromosome
Accession NZ_CP075137
Organism Salmonella enterica strain CFSAN044885

Toxin (Protein)


Gene name higB Uniprot ID A0A8E7K0F6
Locus tag A7S07_RS22540 Protein ID WP_023216604.1
Coordinates 4685147..4685458 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag A7S07_RS22545 Protein ID WP_031618981.1
Coordinates 4685455..4685901 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7S07_RS22510 (4680805) 4680805..4681707 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
A7S07_RS22515 (4681704) 4681704..4682339 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
A7S07_RS22520 (4682336) 4682336..4683265 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
A7S07_RS22525 (4683312) 4683312..4683602 - 291 WP_000362050.1 DNA-binding transcriptional regulator -
A7S07_RS22530 (4683603) 4683603..4683914 - 312 WP_001159632.1 cytotoxic translational repressor of toxin-antitoxin stability system -
A7S07_RS22535 (4684132) 4684132..4685061 + 930 WP_001127706.1 alpha/beta hydrolase -
A7S07_RS22540 (4685147) 4685147..4685458 + 312 WP_023216604.1 type II toxin-antitoxin system HigB family toxin Toxin
A7S07_RS22545 (4685455) 4685455..4685901 + 447 WP_031618981.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
A7S07_RS22550 (4685916) 4685916..4686857 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
A7S07_RS22555 (4686902) 4686902..4687339 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
A7S07_RS22560 (4687336) 4687336..4688205 - 870 WP_023203606.1 virulence factor BrkB family protein -
A7S07_RS22565 (4688199) 4688199..4688798 - 600 WP_000965695.1 glucose-1-phosphatase -
A7S07_RS22570 (4688989) 4688989..4689792 - 804 WP_000059693.1 DeoR/GlpR family DNA-binding transcription regulator -
A7S07_RS22575 (4689826) 4689826..4690722 - 897 WP_001520529.1 sugar kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(93-146)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12432.36 Da        Isoelectric Point: 9.2106

>T203233 WP_023216604.1 NZ_CP075137:4685147-4685458 [Salmonella enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDQWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Download         Length: 312 bp

>T203233 NZ_CP099898:c594889-594425 [Escherichia albertii]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAACCCATCATCATCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGCGCTGGTCGTTATCGTCTCTTCTTTCGTTACAGCGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACACTGCGCACCTACGGTAAAAAAACAGATGCCTATACAGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCAAGAGACAGAAGAAAAGCATTGA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16733.10 Da        Isoelectric Point: 6.9807

>AT203233 WP_031618981.1 NZ_CP075137:4685455-4685901 [Salmonella enterica]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNNNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT203233 NZ_CP099898:c595224-594889 [Escherichia albertii]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCTGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References