Detailed information of TA system TA203232

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4683312..4683914
• Replicon: chromosome
• Accession: NZ_CP075137
• Organism: Salmonella enterica strain CFSAN044885

Toxin (Protein)

• Gene name: higB
• Uniprot ID: V7IUJ1
• Locus tag: A7S07_RS22530
• Protein ID: WP_001159632.1
• Coordinates: 4683603..4683914 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: A7S07_RS22525
• Protein ID: WP_000362050.1
• Coordinates: 4683312..4683602 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7S07_RS22510 (4680805)	4680805..4681707	+	903	WP_000331361.1	formate dehydrogenase subunit beta	-
A7S07_RS22515 (4681704)	4681704..4682339	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
A7S07_RS22520 (4682336)	4682336..4683265	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
A7S07_RS22525 (4683312)	4683312..4683602	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
A7S07_RS22530 (4683603)	4683603..4683914	-	312	WP_001159632.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
A7S07_RS22535 (4684132)	4684132..4685061	+	930	WP_001127706.1	alpha/beta hydrolase	-
A7S07_RS22540 (4685147)	4685147..4685458	+	312	WP_023216604.1	type II toxin-antitoxin system HigB family toxin	-
A7S07_RS22545 (4685455)	4685455..4685901	+	447	WP_031618981.1	type II toxin-antitoxin system HigA family antitoxin	-
A7S07_RS22550 (4685916)	4685916..4686857	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
A7S07_RS22555 (4686902)	4686902..4687339	-	438	WP_000560969.1	D-aminoacyl-tRNA deacylase	-
A7S07_RS22560 (4687336)	4687336..4688205	-	870	WP_023203606.1	virulence factor BrkB family protein	-
A7S07_RS22565 (4688199)	4688199..4688798	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12342.27 Da
• Isoelectric Point: 9.4460

>T203232 WP_001159632.1 NZ_CP075137:c4683914-4683603 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGSRGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T203232 NZ_CP099898:298075-298602 [Escherichia albertii]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTTTGCGAGCGTATATCCTTTGTAGCAACACTC
CAGAACGTCAGGTCCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTCACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCATTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCTCTGAATGAAAAAGCCCATACGTTTTATCAGTCGCTGGGCTTTATCCCGTTGGTTGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACTAAATCCATTGAACTGCTTTTTACACAGAGCGATTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT203232 WP_000362050.1 NZ_CP075137:c4683602-4683312 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT203232 NZ_CP099898:297802-298068 [Escherichia albertii]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAATCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGAGCTGCGGAAGTGATTGAACAGCATCGGCGGA
TGATTCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGTTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Structures

Toxin

• AlphaFold DB: A0A4U7VQ31