Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 2053591..2054318 | Replicon | chromosome |
| Accession | NZ_CP075137 | ||
| Organism | Salmonella enterica strain CFSAN044885 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A8E5IJ81 |
| Locus tag | A7S07_RS09855 | Protein ID | WP_000558157.1 |
| Coordinates | 2054007..2054318 (-) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | A7S07_RS09850 | Protein ID | WP_000561389.1 |
| Coordinates | 2053591..2054010 (-) | Length | 140 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| A7S07_RS09825 (2050399) | 2050399..2050940 | + | 542 | Protein_1923 | transposase | - |
| A7S07_RS09830 (2051086) | 2051086..2051226 | - | 141 | WP_001640444.1 | hypothetical protein | - |
| A7S07_RS09835 (2051392) | 2051392..2051661 | - | 270 | WP_077909686.1 | hypothetical protein | - |
| A7S07_RS09840 (2052031) | 2052031..2052450 | + | 420 | WP_023216650.1 | GNAT family N-acetyltransferase | - |
| A7S07_RS09845 (2052686) | 2052686..2053338 | - | 653 | Protein_1927 | glycosyltransferase | - |
| A7S07_RS09850 (2053591) | 2053591..2054010 | - | 420 | WP_000561389.1 | helix-turn-helix domain-containing protein | Antitoxin |
| A7S07_RS09855 (2054007) | 2054007..2054318 | - | 312 | WP_000558157.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| A7S07_RS09860 (2054497) | 2054497..2054796 | + | 300 | WP_000775226.1 | hypothetical protein | - |
| A7S07_RS09865 (2054826) | 2054826..2055041 | + | 216 | WP_070793957.1 | hypothetical protein | - |
| A7S07_RS09870 (2055095) | 2055095..2055877 | - | 783 | WP_240890580.1 | DUF2971 domain-containing protein | - |
| A7S07_RS09875 (2056240) | 2056240..2056407 | - | 168 | WP_165850592.1 | hypothetical protein | - |
| A7S07_RS09880 (2056528) | 2056528..2057004 | - | 477 | WP_023138823.1 | hypothetical protein | - |
| A7S07_RS09885 (2057333) | 2057333..2057728 | - | 396 | WP_000422887.1 | DUF1398 domain-containing protein | - |
| A7S07_RS09890 (2058413) | 2058413..2059135 | + | 723 | WP_058820973.1 | SPI-1 type III secretion system guanine nucleotide exchange factor SopE2 | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 2050602..2050940 | 338 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12425.26 Da Isoelectric Point: 10.1376
>T203225 WP_000558157.1 NZ_CP075137:c2054318-2054007 [Salmonella enterica]
MHVISKEPFDEAARRYPNDSLAIKALYRLVREKDFSSPAELRKVIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFINKRF
YVKHIATHAEYDKLTRYYRENKE
MHVISKEPFDEAARRYPNDSLAIKALYRLVREKDFSSPAELRKVIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFINKRF
YVKHIATHAEYDKLTRYYRENKE
Download Length: 312 bp
>T203225 NZ_CP099895:c4032928-4032551 [Escherichia albertii]
ATGAACACATTACCCGATACACACGTACGGGAGGCATCGCATTGCCAGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGGATTC
AGCGTCTGTACTCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA
ATGAACACATTACCCGATACACACGTACGGGAGGCATCGCATTGCCAGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGGATTC
AGCGTCTGTACTCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA
Antitoxin
Download Length: 140 a.a. Molecular weight: 15301.49 Da Isoelectric Point: 4.6286
>AT203225 WP_000561389.1 NZ_CP075137:c2054010-2053591 [Salmonella enterica]
MIANTAKAIEATKALVAAVPFLGGSASEKDYRDALALVDYLIENDDENPLIDFLASKIAEYEDNSKQFAEFNKSVAEMPV
GVALLRTLIDQYKLSYSDLKEEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
MIANTAKAIEATKALVAAVPFLGGSASEKDYRDALALVDYLIENDDENPLIDFLASKIAEYEDNSKQFAEFNKSVAEMPV
GVALLRTLIDQYKLSYSDLKEEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
Download Length: 420 bp
>AT203225 NZ_CP099895:c4033386-4033018 [Escherichia albertii]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAAGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAAGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|