Detailed information of TA system TA203208

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4678646..4679248
• Replicon: chromosome
• Accession: NZ_CP075135
• Organism: Salmonella enterica strain CFSAN044888

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A3V8XMR3
• Locus tag: A7S10_RS22680
• Protein ID: WP_001159631.1
• Coordinates: 4678937..4679248 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: A7S10_RS22675
• Protein ID: WP_000362050.1
• Coordinates: 4678646..4678936 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7S10_RS22660 (4676139)	4676139..4677041	+	903	WP_000331361.1	formate dehydrogenase subunit beta	-
A7S10_RS22665 (4677038)	4677038..4677673	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
A7S10_RS22670 (4677670)	4677670..4678599	+	930	WP_070794361.1	formate dehydrogenase accessory protein FdhE	-
A7S10_RS22675 (4678646)	4678646..4678936	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
A7S10_RS22680 (4678937)	4678937..4679248	-	312	WP_001159631.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
A7S10_RS22685 (4679466)	4679466..4680395	+	930	WP_001646963.1	alpha/beta hydrolase	-
A7S10_RS22690 (4680481)	4680481..4680792	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
A7S10_RS22695 (4680789)	4680789..4681235	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	-
A7S10_RS22700 (4681250)	4681250..4682191	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
A7S10_RS22705 (4682236)	4682236..4682673	-	438	WP_000560969.1	D-aminoacyl-tRNA deacylase	-
A7S10_RS22710 (4682670)	4682670..4683542	-	873	WP_000921423.1	virulence factor BrkB family protein	-
A7S10_RS22715 (4683536)	4683536..4684135	-	600	WP_001646959.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12312.25 Da
• Isoelectric Point: 9.4460

>T203208 WP_001159631.1 NZ_CP075135:c4679248-4678937 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEVRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T203208 NZ_CP099893:92209-92730 [Escherichia albertii]
GTGAGCAATACAACGATAGAGATTTTCTCTGGAGAGAAAGATTATGATCTAAACGGTTTTGATTGCGGCGAAGAGTCACT
AAACGCCTTTTTAGCCAACCACTTAAAAAGGCAGCATGAGGGAAAAATTCTTCGTGCTTATGTGCTTTGCACTCAAGAAG
AAAGGCCAAAAGTGTTAGGATATTACACTTTGTCAGGTAGTTGTTTTGAAAAGGAGTCCTTACCTTCAAGAAGCAAACAA
AAGAAGGTTCCTTATCGGAATGTTCCAAGTGTTACTTTGGGTAGGCTGGCTTTGGACAAGTCCCTTCAAGGTCAAGGATT
TGGCTCAATGCTTGTAACACATGCAATGCGCGTTGTGTACAATGCATCTCTTGCTGTAGGCATTCATGGACTTTTCGTTG
AGGCGTTAAATGACAAAGCCAAGGCGTTTTATAAAAGTTTAGGCTTTATCCAGCTGGTTGGTAACAACGAGCGTTCTTTG
TTCTATCCTACAAAATCTATCGAAAAATTGTTCGAAGAATAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT203208 WP_000362050.1 NZ_CP075135:c4678936-4678646 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT203208 NZ_CP099893:91932-92201 [Escherichia albertii]
ATGTCAGCACTAAAAAAGCAGCGCATCGATTTGAGATTAACCGATGACGATAAAAGCATCATCGAGGAAGCTGCCGCAAT
GTCTAACCAGAGCATTACTCAGTTTATGGTTAGCAGTGCATCTGAACGTGCCGTGAAAGTTATAGAGCAACACCGTAGAC
TAGTTCTGAATGAAGAATCCTGGAATCTGGTTATGGACGCTATAAGCAATCCTCCGGCACCGAACGACAAGCTGAAACGA
GCTGCTGATCGTCTGAAAAGCATGGAGTAG

Structures

Toxin

• AlphaFold DB: A0A3V8XMR3