Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 4601373..4602127 | Replicon | chromosome |
| Accession | NZ_CP075134 | ||
| Organism | Salmonella enterica subsp. enterica serovar Saintpaul strain CFSAN044909 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | B5F003 |
| Locus tag | A7S31_RS22310 | Protein ID | WP_000558166.1 |
| Coordinates | 4601373..4601684 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | A7S31_RS22315 | Protein ID | WP_001259012.1 |
| Coordinates | 4601681..4602127 (+) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| A7S31_RS22280 (4597039) | 4597039..4597941 | + | 903 | WP_000331364.1 | formate dehydrogenase subunit beta | - |
| A7S31_RS22285 (4597938) | 4597938..4598573 | + | 636 | WP_000829025.1 | formate dehydrogenase cytochrome b556 subunit | - |
| A7S31_RS22290 (4598570) | 4598570..4599499 | + | 930 | WP_000027730.1 | formate dehydrogenase accessory protein FdhE | - |
| A7S31_RS22295 (4599537) | 4599537..4599911 | - | 375 | WP_000238494.1 | type II toxin-antitoxin system VapC family toxin | - |
| A7S31_RS22300 (4599911) | 4599911..4600153 | - | 243 | WP_001523745.1 | CopG family transcriptional regulator | - |
| A7S31_RS22305 (4600358) | 4600358..4601287 | + | 930 | WP_001523720.1 | alpha/beta hydrolase | - |
| A7S31_RS22310 (4601373) | 4601373..4601684 | + | 312 | WP_000558166.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| A7S31_RS22315 (4601681) | 4601681..4602127 | + | 447 | WP_001259012.1 | type II toxin-antitoxin system HigA family antitoxin | Antitoxin |
| A7S31_RS22320 (4602142) | 4602142..4603083 | - | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
| A7S31_RS22325 (4603128) | 4603128..4603565 | - | 438 | WP_000560956.1 | D-aminoacyl-tRNA deacylase | - |
| A7S31_RS22330 (4603562) | 4603562..4604434 | - | 873 | WP_001523799.1 | virulence factor BrkB family protein | - |
| A7S31_RS22335 (4604428) | 4604428..4605027 | - | 600 | WP_000965695.1 | glucose-1-phosphatase | - |
| A7S31_RS22340 (4605218) | 4605218..4606021 | - | 804 | WP_000059693.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
| A7S31_RS22345 (4606055) | 4606055..4606951 | - | 897 | WP_001520529.1 | sugar kinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12432.40 Da Isoelectric Point: 9.5334
>T203193 WP_000558166.1 NZ_CP075134:4601373-4601684 [Salmonella enterica subsp. enterica serovar Saintpaul]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
Download Length: 312 bp
>T203193 NZ_CP099892:142033-142218 [Escherichia albertii]
GTGAAAAGTGCAGACGTGATCGCCATCCTGAAGCAGCATGGCTGGGAACATATTCGAACCCGTGGCAGTCATCATCAGTT
CCGCCACCCTGTTCATCCGGGTCTGGTGACGGTTCCGCACCCTAAAAAAGATATTAAGCCCGGTACGCTGGCGCAAATTG
GGCGTCAGGCTGGTTTAACATTTTAA
GTGAAAAGTGCAGACGTGATCGCCATCCTGAAGCAGCATGGCTGGGAACATATTCGAACCCGTGGCAGTCATCATCAGTT
CCGCCACCCTGTTCATCCGGGTCTGGTGACGGTTCCGCACCCTAAAAAAGATATTAAGCCCGGTACGCTGGCGCAAATTG
GGCGTCAGGCTGGTTTAACATTTTAA
Antitoxin
Download Length: 149 a.a. Molecular weight: 16750.08 Da Isoelectric Point: 6.6451
>AT203193 WP_001259012.1 NZ_CP075134:4601681-4602127 [Salmonella enterica subsp. enterica serovar Saintpaul]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKSLN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKSLN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
Download Length: 447 bp
>AT203193 NZ_CP099892:142235-142645 [Escherichia albertii]
ATGTTTTATCCCGCCTATATCCACAGTGATCCTGACGGCAGCGCCAGCGGTTTTTTCCCTGATGTTCCAGGCTGTTATTT
TGCTGGGGATACGCTGGACAACGCTTTCCAGGATGCGCGAAGTGCACTGGTCGCGCACTTCGAAACCTTATGCGAGATGA
ATGAAGAGTTGCCGCTTCCAGGCTCTGTGGAAACACATCTGGTTCAGCGTGCGCAGGACTTTATTGGCGGGCAATGGTTG
CTGGTGGATATCAATATGAATCAGGTCGAAGGTCGGGCTGAACGTATCAATATTACGATGCCAAAAAGATTACTGAACAA
GATTGATACCTACGTGCGCAATAACCCAGACTACGCCAACAGAAGTGCGTTTCTGGCGGAAGCTGCCCGGCGTGTATTGC
CGGGCGTTTAA
ATGTTTTATCCCGCCTATATCCACAGTGATCCTGACGGCAGCGCCAGCGGTTTTTTCCCTGATGTTCCAGGCTGTTATTT
TGCTGGGGATACGCTGGACAACGCTTTCCAGGATGCGCGAAGTGCACTGGTCGCGCACTTCGAAACCTTATGCGAGATGA
ATGAAGAGTTGCCGCTTCCAGGCTCTGTGGAAACACATCTGGTTCAGCGTGCGCAGGACTTTATTGGCGGGCAATGGTTG
CTGGTGGATATCAATATGAATCAGGTCGAAGGTCGGGCTGAACGTATCAATATTACGATGCCAAAAAGATTACTGAACAA
GATTGATACCTACGTGCGCAATAACCCAGACTACGCCAACAGAAGTGCGTTTCTGGCGGAAGCTGCCCGGCGTGTATTGC
CGGGCGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|