203185

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 2697441..2697969 Replicon chromosome
Accession NZ_CP075134
Organism Salmonella enterica subsp. enterica serovar Saintpaul strain CFSAN044909

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag A7S31_RS23415 Protein ID WP_108429764.1
Coordinates 2697441..2697671 (+) Length 77 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag A7S31_RS23420 Protein ID WP_000147078.1
Coordinates 2697661..2697969 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7S31_RS13155 (2692676) 2692676..2692876 + 201 WP_033578003.1 phage virulence factor PagK family protein -
A7S31_RS13160 (2692973) 2692973..2693383 - 411 WP_001525515.1 tail fiber assembly protein -
A7S31_RS13165 (2693390) 2693390..2693488 - 99 Protein_2591 phage tail protein -
A7S31_RS13170 (2693490) 2693490..2694812 - 1323 Protein_2592 DNA circularization N-terminal domain-containing protein -
A7S31_RS13175 (2694846) 2694846..2695247 - 402 WP_001525519.1 hypothetical protein -
A7S31_RS13180 (2695253) 2695253..2695528 - 276 Protein_2594 phage tail tube protein -
A7S31_RS13185 (2695528) 2695528..2695743 - 216 Protein_2595 phage tail protein -
A7S31_RS13190 (2695736) 2695736..2696260 - 525 Protein_2596 helix-turn-helix domain-containing protein -
A7S31_RS13195 (2696257) 2696257..2696481 - 225 WP_000620702.1 hypothetical protein -
A7S31_RS23410 (2696478) 2696478..2697476 - 999 WP_237703493.1 Rha family phage regulatory protein -
A7S31_RS23415 (2697441) 2697441..2697671 + 231 WP_108429764.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A7S31_RS23420 (2697661) 2697661..2697969 + 309 WP_000147078.1 helix-turn-helix transcriptional regulator Antitoxin
A7S31_RS23425 (2697988) 2697988..2698164 - 177 WP_001525520.1 DUF4222 domain-containing protein -
A7S31_RS13205 (2698304) 2698304..2698858 - 555 WP_000509733.1 YmfL family putative regulatory protein -
A7S31_RS13210 (2698887) 2698887..2699111 - 225 WP_001191666.1 helix-turn-helix transcriptional regulator -
A7S31_RS13215 (2699209) 2699209..2699904 + 696 WP_058671845.1 helix-turn-helix transcriptional regulator -
A7S31_RS13220 (2700113) 2700113..2700421 + 309 WP_023262052.1 hypothetical protein -
A7S31_RS13225 (2700359) 2700359..2700697 - 339 WP_071586821.1 hypothetical protein -
A7S31_RS23430 (2700894) 2700894..2701025 + 132 Protein_2607 hypothetical protein -
A7S31_RS13230 (2701065) 2701065..2701301 + 237 Protein_2608 hypothetical protein -
A7S31_RS13235 (2701359) 2701359..2702186 + 828 WP_070810915.1 DUF2303 family protein -
A7S31_RS13240 (2702323) 2702323..2702862 + 540 WP_000008352.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - sopE2 / sspH1 2662355..2704373 42018


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(5-70)

Antitoxin

Cro/C1-type helix-turn-helix domain

(44-94)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8640.11 Da        Isoelectric Point: 10.5308

>T203185 WP_108429764.1 NZ_CP075134:2697441-2697671 [Salmonella enterica subsp. enterica serovar Saintpaul]
MKVYGSNLGEPHTSAFGDGLFELRIKGSDGIARVFYCTLAGKRIVMLHSFIKKTQKTPVAERKKAETRMKEVKHDW

Download         Length: 231 bp

>T203185 NZ_CP099890:c2092024-2091722 [Escherichia albertii]
ATGACCAAAAAAATTAACATAAAGGATTTCAGGGATGCGTGGCTTGATGATTTTTTTGAATTTTCAACACCACACAAAAA
GATACCTTCTGATATTCATATTACATTGTTGCGGAAGCTGGATATTATCAATGCCGCAACTACCTGGAAGGACTTGAGAT
CACCACCAGGTAATCGGTATGAAGAATTGTCAGGGAAGCTAAACGGCTATTCATCAATAAGGGTGAATAATCAATATAGG
TTAATTTTTAAGTGGGTTAACGGAAAGGCCGAGGACTTGTATCTCGACCCTCACAAATACTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11110.77 Da        Isoelectric Point: 7.0152

>AT203185 WP_000147078.1 NZ_CP075134:2697661-2697969 [Salmonella enterica subsp. enterica serovar Saintpaul]
MTGKRNAPTITHDEMAAKWMEDPAFKAEYDAIADEFALLDEMLAARKEAGLTQAEVAERMGTKATAITRMESNLAAGVSG
PSFTTLKKFAQATGKKLQIRFV

Download         Length: 309 bp

>AT203185 NZ_CP099890:c2091650-2091312 [Escherichia albertii]
ATGAAACAGGCAACCAGAAAACCGACGACTGTAGGTGATATCCTGCTGTACGAATACCTGGAGCCGTTAGAGCTTAAGAT
CAACGAGTTAGCAGAAATACTTCATGTTCATCGCAACACCGTAAGTGCTCTTGTTAATAATAATCGTAAGCTAACGATGG
ATATGGCATATCGCCTGGCAAAAGCATTCGATACTTCTGTAGATTTTTGGATTAATCTTCAGACCGCAGTAGACCTGTGG
GAAGTTGAAAATGATATGCGCGTTCAGGAAGAGTTAAGCCGTATCACTACTGCTGAAGAATTTATTTCTCAGCGGAATCT
GAATAAAAAAGCAGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References