Detailed information of TA system TA203170

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4777624..4778226
• Replicon: chromosome
• Accession: NZ_CP075132
• Organism: Salmonella enterica subsp. enterica serovar Inverness strain CFSAN044911

Toxin (Protein)

• Gene name: higB
• Uniprot ID: M7S4R6
• Locus tag: A7S33_RS23425
• Protein ID: WP_001159635.1
• Coordinates: 4777915..4778226 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: A7S33_RS23420
• Protein ID: WP_000362050.1
• Coordinates: 4777624..4777914 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7S33_RS23405 (4775117)	4775117..4776019	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
A7S33_RS23410 (4776016)	4776016..4776651	+	636	WP_000829028.1	formate dehydrogenase cytochrome b556 subunit	-
A7S33_RS23415 (4776648)	4776648..4777577	+	930	WP_000027736.1	formate dehydrogenase accessory protein FdhE	-
A7S33_RS23420 (4777624)	4777624..4777914	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
A7S33_RS23425 (4777915)	4777915..4778226	-	312	WP_001159635.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
A7S33_RS23430 (4778444)	4778444..4779373	+	930	WP_001627365.1	alpha/beta hydrolase	-
A7S33_RS23435 (4779459)	4779459..4779770	+	312	WP_000558163.1	type II toxin-antitoxin system HigB family toxin	-
A7S33_RS23440 (4779767)	4779767..4780213	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	-
A7S33_RS23445 (4780228)	4780228..4781169	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
A7S33_RS23450 (4781214)	4781214..4781651	-	438	WP_001627364.1	D-aminoacyl-tRNA deacylase	-
A7S33_RS23455 (4781648)	4781648..4782520	-	873	WP_001627363.1	virulence factor BrkB family protein	-
A7S33_RS23460 (4782514)	4782514..4783113	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12340.30 Da
• Isoelectric Point: 9.4460

>T203170 WP_001159635.1 NZ_CP075132:c4778226-4777915 [Salmonella enterica subsp. enterica serovar Inverness]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T203170 NZ_CP099887:2439470-2439748 [Escherichia albertii]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCTGCAAGCAGTCTTGTTGATATCGATATGCCCGGTTACCGACTAC
ACCCATTAAGCGGCGATCGCGATGGCATCTGGGCAATATCTGTATCAGGCAACTGGCGAATCACGTTTGAGTTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT203170 WP_000362050.1 NZ_CP075132:c4777914-4777624 [Salmonella enterica subsp. enterica serovar Inverness]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT203170 NZ_CP099887:2439748-2440032 [Escherichia albertii]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTGAACGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGACTGTTGACCGGAAAAGCGGCTTTGACGCCAGAAATGGCGA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCTGAG
AAAACGGTGGATGTGTCGCGGTTGCGCCGTCTGGTTGCGCAATAA

Structures

Toxin

• AlphaFold DB: A0A3V2JK97