Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/Tad-HTH_37 |
| Location | 1995492..1996020 | Replicon | chromosome |
| Accession | NZ_CP075132 | ||
| Organism | Salmonella enterica subsp. enterica serovar Inverness strain CFSAN044911 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | A7S33_RS25195 | Protein ID | WP_108429764.1 |
| Coordinates | 1995492..1995722 (+) | Length | 77 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | A7S33_RS25200 | Protein ID | WP_000147078.1 |
| Coordinates | 1995712..1996020 (+) | Length | 103 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| A7S33_RS10100 (1991193) | 1991193..1991582 | - | 390 | WP_001529171.1 | RusA family crossover junction endodeoxyribonuclease | - |
| A7S33_RS10105 (1991579) | 1991579..1992232 | - | 654 | WP_001624543.1 | phage N-6-adenine-methyltransferase | - |
| A7S33_RS10110 (1992232) | 1992232..1992714 | - | 483 | WP_070810381.1 | PerC family transcriptional regulator | - |
| A7S33_RS10115 (1992716) | 1992716..1993675 | - | 960 | WP_070810380.1 | helix-turn-helix domain-containing protein | - |
| A7S33_RS10120 (1993672) | 1993672..1993896 | - | 225 | WP_000620702.1 | hypothetical protein | - |
| A7S33_RS25185 (1993893) | 1993893..1994438 | - | 546 | WP_253185772.1 | Rha family transcriptional regulator | - |
| A7S33_RS25190 (1994754) | 1994754..1995527 | - | 774 | Protein_2006 | Rha family transcriptional regulator | - |
| A7S33_RS25195 (1995492) | 1995492..1995722 | + | 231 | WP_108429764.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| A7S33_RS25200 (1995712) | 1995712..1996020 | + | 309 | WP_000147078.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| A7S33_RS25205 (1996039) | 1996039..1996215 | - | 177 | WP_001525520.1 | DUF4222 domain-containing protein | - |
| A7S33_RS10130 (1996355) | 1996355..1996909 | - | 555 | WP_070811212.1 | YmfL family putative regulatory protein | - |
| A7S33_RS10135 (1996938) | 1996938..1997162 | - | 225 | WP_001191666.1 | helix-turn-helix transcriptional regulator | - |
| A7S33_RS10140 (1997260) | 1997260..1997955 | + | 696 | WP_001020640.1 | helix-turn-helix transcriptional regulator | - |
| A7S33_RS10145 (1998290) | 1998290..1998487 | - | 198 | WP_001624554.1 | hypothetical protein | - |
| A7S33_RS25210 (1998683) | 1998683..1998827 | + | 145 | Protein_2014 | hypothetical protein | - |
| A7S33_RS10150 (1999026) | 1999026..1999397 | + | 372 | WP_000997190.1 | hypothetical protein | - |
| A7S33_RS10155 (1999455) | 1999455..2000282 | + | 828 | WP_058819372.1 | DUF2303 family protein | - |
| A7S33_RS10160 (2000419) | 2000419..2000958 | + | 540 | WP_000008351.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | sspH2 / sspH2 | 1958331..2011401 | 53070 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 77 a.a. Molecular weight: 8640.11 Da Isoelectric Point: 10.5308
>T203164 WP_108429764.1 NZ_CP075132:1995492-1995722 [Salmonella enterica subsp. enterica serovar Inverness]
MKVYGSNLGEPHTSAFGDGLFELRIKGSDGIARVFYCTLAGKRIVMLHSFIKKTQKTPVAERKKAETRMKEVKHDW
MKVYGSNLGEPHTSAFGDGLFELRIKGSDGIARVFYCTLAGKRIVMLHSFIKKTQKTPVAERKKAETRMKEVKHDW
Download Length: 231 bp
>T203164 NZ_CP099887:635397-635711 [Escherichia albertii]
ATGCACCTGATCACTCAAAAAGCATTGAAAGATGCAGCGGAAAAATATCCGCAGCATAAAACGGAGTTGGTGGCACTGGG
GAACACGATTGCTAAGGGATACTTCAAAAAACCTGAGTCATTAAAAGCAGTGTTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCACAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA
ATGCACCTGATCACTCAAAAAGCATTGAAAGATGCAGCGGAAAAATATCCGCAGCATAAAACGGAGTTGGTGGCACTGGG
GAACACGATTGCTAAGGGATACTTCAAAAAACCTGAGTCATTAAAAGCAGTGTTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCACAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA
Antitoxin
Download Length: 103 a.a. Molecular weight: 11110.77 Da Isoelectric Point: 7.0152
>AT203164 WP_000147078.1 NZ_CP075132:1995712-1996020 [Salmonella enterica subsp. enterica serovar Inverness]
MTGKRNAPTITHDEMAAKWMEDPAFKAEYDAIADEFALLDEMLAARKEAGLTQAEVAERMGTKATAITRMESNLAAGVSG
PSFTTLKKFAQATGKKLQIRFV
MTGKRNAPTITHDEMAAKWMEDPAFKAEYDAIADEFALLDEMLAARKEAGLTQAEVAERMGTKATAITRMESNLAAGVSG
PSFTTLKKFAQATGKKLQIRFV
Download Length: 309 bp
>AT203164 NZ_CP099887:635708-636124 [Escherichia albertii]
ATGATTGCGATTGCCGATATCTTGCAAGCAGGAGAAAAGCTAACCGATGTGGCACCTTTTCTGGCGGGTATCCAGAGCGA
AGAACAGTATGCCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAATCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCTGAATTTAATGCGATGGTTCAAGCCATGCCTGGCGGT
GTTGCTGTGATTCGTACCCTGATGGATCAATACGGCTTAACCCTTTCCGATCTTCCAGAAATTGGCAGTAAATCCATGGT
GTCACGCGTTTTGAACGGGAAGAGAAAATTAACGCTGGAACACGCTAAAAAACTGGCAGCGCGATTCGGCATTTCCCCTG
CGTTGTTTATTGATTAA
ATGATTGCGATTGCCGATATCTTGCAAGCAGGAGAAAAGCTAACCGATGTGGCACCTTTTCTGGCGGGTATCCAGAGCGA
AGAACAGTATGCCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAATCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCTGAATTTAATGCGATGGTTCAAGCCATGCCTGGCGGT
GTTGCTGTGATTCGTACCCTGATGGATCAATACGGCTTAACCCTTTCCGATCTTCCAGAAATTGGCAGTAAATCCATGGT
GTCACGCGTTTTGAACGGGAAGAGAAAATTAACGCTGGAACACGCTAAAAAACTGGCAGCGCGATTCGGCATTTCCCCTG
CGTTGTTTATTGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|