Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 360301..360839 Replicon chromosome
Accession NZ_CP075132
Organism Salmonella enterica subsp. enterica serovar Inverness strain CFSAN044911

Toxin (Protein)


Gene name yafQ Uniprot ID A0A486WWL6
Locus tag A7S33_RS01630 Protein ID WP_001626961.1
Coordinates 360564..360839 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A7U1KUN1
Locus tag A7S33_RS01625 Protein ID WP_000729714.1
Coordinates 360301..360561 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7S33_RS01610 (356054) 356054..357607 + 1554 WP_023227917.1 TROVE domain-containing protein -
A7S33_RS01615 (357955) 357955..359169 + 1215 WP_070793431.1 RNA-splicing ligase RtcB -
A7S33_RS01620 (359173) 359173..360192 + 1020 WP_000101027.1 RNA 3'-terminal phosphate cyclase -
A7S33_RS01625 (360301) 360301..360561 + 261 WP_000729714.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
A7S33_RS01630 (360564) 360564..360839 + 276 WP_001626961.1 type II toxin-antitoxin system YafQ family toxin Toxin
A7S33_RS01635 (360927) 360927..363632 - 2706 WP_000907030.1 HTH-type transcriptional regulator MalT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10619.19 Da        Isoelectric Point: 8.9063

>T203155 WP_001626961.1 NZ_CP075132:360564-360839 [Salmonella enterica subsp. enterica serovar Inverness]
MGQREIEYSGQFQKDVKRAQKRHKDVGKLKTLMTLLIHHPFPLPAIYKDHPLQGSYSGYRDAHIGPDWILIDKITDECLR
FERTGTHADLF

Download         Length: 276 bp

>T203155 NZ_CP099886:c4361047-4360892 [Escherichia albertii]
ATGAAGCAGCAAAAGGCGATGTTAGTCGCCCTGATCGTCATCTGTTTAACCGTCATTGTTACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGTCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9445.82 Da        Isoelectric Point: 4.6028

>AT203155 WP_000729714.1 NZ_CP075132:360301-360561 [Salmonella enterica subsp. enterica serovar Inverness]
MAANALVRARIDETLKNQAADVLAEMGLTISDLIRITLTKVAREKALPFDLRIPNELTSRTIENSEAGVDIHKAKDADDL
FDQLGI

Download         Length: 261 bp

>AT203155 NZ_CP099886:4361059-4361117 [Escherichia albertii]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486WWL6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U1KUN1

References