Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4677909..4678663 Replicon chromosome
Accession NZ_CP075129
Organism Salmonella enterica subsp. enterica serovar Rubislaw strain CFSAN044921

Toxin (Protein)


Gene name higB Uniprot ID B5F003
Locus tag A7S43_RS22660 Protein ID WP_000558166.1
Coordinates 4677909..4678220 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag A7S43_RS22665 Protein ID WP_001259011.1
Coordinates 4678217..4678663 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7S43_RS22630 (4673567) 4673567..4674469 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
A7S43_RS22635 (4674466) 4674466..4675101 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
A7S43_RS22640 (4675098) 4675098..4676027 + 930 WP_070794361.1 formate dehydrogenase accessory protein FdhE -
A7S43_RS22645 (4676074) 4676074..4676364 - 291 WP_000362050.1 DNA-binding transcriptional regulator -
A7S43_RS22650 (4676365) 4676365..4676676 - 312 WP_001159631.1 cytotoxic translational repressor of toxin-antitoxin stability system -
A7S43_RS22655 (4676894) 4676894..4677823 + 930 WP_001646963.1 alpha/beta hydrolase -
A7S43_RS22660 (4677909) 4677909..4678220 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin Toxin
A7S43_RS22665 (4678217) 4678217..4678663 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
A7S43_RS22670 (4678678) 4678678..4679619 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
A7S43_RS22675 (4679664) 4679664..4680101 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
A7S43_RS22680 (4680098) 4680098..4680970 - 873 WP_000921423.1 virulence factor BrkB family protein -
A7S43_RS22685 (4680964) 4680964..4681563 - 600 WP_001646959.1 glucose-1-phosphatase -
A7S43_RS22690 (4681754) 4681754..4682557 - 804 WP_023137059.1 DeoR/GlpR family DNA-binding transcription regulator -
A7S43_RS22695 (4682591) 4682591..4683487 - 897 WP_001520529.1 sugar kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(93-146)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12432.40 Da        Isoelectric Point: 9.5334

>T203150 WP_000558166.1 NZ_CP075129:4677909-4678220 [Salmonella enterica subsp. enterica serovar Rubislaw]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Download         Length: 312 bp

>T203150 NZ_CP099886:c2723344-2723192 [Escherichia albertii]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTCTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16734.08 Da        Isoelectric Point: 6.6451

>AT203150 WP_001259011.1 NZ_CP075129:4678217-4678663 [Salmonella enterica subsp. enterica serovar Rubislaw]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT203150 NZ_CP099886:2723393-2723450 [Escherichia albertii]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9ME90

Antitoxin

Source ID Structure

References