Detailed information of TA system TA203149

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4676074..4676676
• Replicon: chromosome
• Accession: NZ_CP075129
• Organism: Salmonella enterica subsp. enterica serovar Rubislaw strain CFSAN044921

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A3V8XMR3
• Locus tag: A7S43_RS22650
• Protein ID: WP_001159631.1
• Coordinates: 4676365..4676676 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: A7S43_RS22645
• Protein ID: WP_000362050.1
• Coordinates: 4676074..4676364 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7S43_RS22630 (4673567)	4673567..4674469	+	903	WP_000331361.1	formate dehydrogenase subunit beta	-
A7S43_RS22635 (4674466)	4674466..4675101	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
A7S43_RS22640 (4675098)	4675098..4676027	+	930	WP_070794361.1	formate dehydrogenase accessory protein FdhE	-
A7S43_RS22645 (4676074)	4676074..4676364	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
A7S43_RS22650 (4676365)	4676365..4676676	-	312	WP_001159631.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
A7S43_RS22655 (4676894)	4676894..4677823	+	930	WP_001646963.1	alpha/beta hydrolase	-
A7S43_RS22660 (4677909)	4677909..4678220	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
A7S43_RS22665 (4678217)	4678217..4678663	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	-
A7S43_RS22670 (4678678)	4678678..4679619	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
A7S43_RS22675 (4679664)	4679664..4680101	-	438	WP_000560969.1	D-aminoacyl-tRNA deacylase	-
A7S43_RS22680 (4680098)	4680098..4680970	-	873	WP_000921423.1	virulence factor BrkB family protein	-
A7S43_RS22685 (4680964)	4680964..4681563	-	600	WP_001646959.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12312.25 Da
• Isoelectric Point: 9.4460

>T203149 WP_001159631.1 NZ_CP075129:c4676676-4676365 [Salmonella enterica subsp. enterica serovar Rubislaw]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEVRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T203149 NZ_CP099886:c2599509-2599168 [Escherichia albertii]
ATGACTGACACGCATTCTATTGCACAACAGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGCCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGCGATAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCACCCCCCCGCCGCCGAAGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCAGGAATTTATTGGGGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT203149 WP_000362050.1 NZ_CP075129:c4676364-4676074 [Salmonella enterica subsp. enterica serovar Rubislaw]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT203149 NZ_CP099886:2599504-2599580 [Escherichia albertii]
AGTCATGATTACTATTCCTTAGAAATAGGGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: A0A3V8XMR3