Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4995318..4996072 Replicon chromosome
Accession NZ_CP075128
Organism Salmonella enterica subsp. diarizonae serovar 60:r:enxz15 strain CFSAN044923

Toxin (Protein)


Gene name higB Uniprot ID B5F003
Locus tag A7S45_RS24050 Protein ID WP_000558166.1
Coordinates 4995318..4995629 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag A7S45_RS24055 Protein ID WP_001259011.1
Coordinates 4995626..4996072 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7S45_RS24020 (4990987) 4990987..4991889 + 903 WP_070789960.1 formate dehydrogenase subunit beta -
A7S45_RS24025 (4991886) 4991886..4992521 + 636 WP_000829028.1 formate dehydrogenase cytochrome b556 subunit -
A7S45_RS24030 (4992518) 4992518..4993447 + 930 WP_023249115.1 formate dehydrogenase accessory protein FdhE -
A7S45_RS24035 (4993485) 4993485..4993859 - 375 WP_023249114.1 type II toxin-antitoxin system VapC family toxin -
A7S45_RS24040 (4993859) 4993859..4994101 - 243 WP_001523745.1 CopG family transcriptional regulator -
A7S45_RS24045 (4994306) 4994306..4995232 + 927 Protein_4743 alpha/beta hydrolase -
A7S45_RS24050 (4995318) 4995318..4995629 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin Toxin
A7S45_RS24055 (4995626) 4995626..4996072 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
A7S45_RS24060 (4996087) 4996087..4997028 - 942 WP_024134888.1 fatty acid biosynthesis protein FabY -
A7S45_RS24065 (4997073) 4997073..4997510 - 438 WP_023249111.1 D-aminoacyl-tRNA deacylase -
A7S45_RS24070 (4997507) 4997507..4998379 - 873 WP_023249110.1 virulence factor BrkB family protein -
A7S45_RS24075 (4998373) 4998373..4998972 - 600 WP_023249109.1 glucose-1-phosphatase -
A7S45_RS24080 (4999163) 4999163..4999966 - 804 WP_023249108.1 DeoR/GlpR family DNA-binding transcription regulator -
A7S45_RS24085 (5000000) 5000000..5000896 - 897 WP_023249107.1 sugar kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(93-146)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12432.40 Da        Isoelectric Point: 9.5334

>T203134 WP_000558166.1 NZ_CP075128:4995318-4995629 [Salmonella enterica subsp. diarizonae serovar 60:r:e,n,x,z15]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Download         Length: 312 bp

>T203134 NZ_CP099883:c3281483-3281331 [Escherichia albertii]
ATGCTAACAAAATATGCCCTTGTGGCAATCATCGTACTGTGTTGTACAGTACTGGGATTCACGCTGATGGTAGGCGACTC
GCTGTGTGAGTTGAGTATCAGAGAACGTGGTATGGAGTTTAAGGCAGTTCTCGCTTACGAATCGAAGAAGTAG

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16734.08 Da        Isoelectric Point: 6.6451

>AT203134 WP_001259011.1 NZ_CP075128:4995626-4996072 [Salmonella enterica subsp. diarizonae serovar 60:r:e,n,x,z15]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT203134 NZ_CP099883:3281525-3281577 [Escherichia albertii]
TTAGGTTCGAACGCTGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9ME90

Antitoxin

Source ID Structure

References