Detailed information of TA system TA203117

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 4560070..4560824
• Replicon: chromosome
• Accession: NZ_CP075127
• Organism: Salmonella enterica strain CFSAN044925

Toxin (Protein)

• Gene name: higB
• Uniprot ID: B5F003
• Locus tag: A7S47_RS21975
• Protein ID: WP_000558166.1
• Coordinates: 4560070..4560381 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: A7S47_RS21980
• Protein ID: WP_001259012.1
• Coordinates: 4560378..4560824 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7S47_RS21945 (4555736)	4555736..4556638	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
A7S47_RS21950 (4556635)	4556635..4557270	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
A7S47_RS21955 (4557267)	4557267..4558196	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
A7S47_RS21960 (4558234)	4558234..4558608	-	375	WP_000238494.1	type II toxin-antitoxin system VapC family toxin	-
A7S47_RS21965 (4558608)	4558608..4558850	-	243	WP_001523745.1	CopG family transcriptional regulator	-
A7S47_RS21970 (4559055)	4559055..4559984	+	930	WP_001523720.1	alpha/beta hydrolase	-
A7S47_RS21975 (4560070)	4560070..4560381	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	Toxin
A7S47_RS21980 (4560378)	4560378..4560824	+	447	WP_001259012.1	type II toxin-antitoxin system HigA family antitoxin	Antitoxin
A7S47_RS21985 (4560839)	4560839..4561780	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
A7S47_RS21990 (4561825)	4561825..4562262	-	438	WP_000560956.1	D-aminoacyl-tRNA deacylase	-
A7S47_RS21995 (4562259)	4562259..4563131	-	873	WP_001523799.1	virulence factor BrkB family protein	-
A7S47_RS22000 (4563125)	4563125..4563724	-	600	WP_000965695.1	glucose-1-phosphatase	-
A7S47_RS22005 (4563915)	4563915..4564718	-	804	WP_000059693.1	DeoR/GlpR family DNA-binding transcription regulator	-
A7S47_RS22010 (4564752)	4564752..4565648	-	897	WP_001520529.1	sugar kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, mRNA interferase HigB (21-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (93-146)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12432.40 Da
• Isoelectric Point: 9.5334

>T203117 WP_000558166.1 NZ_CP075127:4560070-4560381 [Salmonella enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Nucleotide

• Length: 312 bp

>T203117 NZ_CP099880:4093369-4093710 [Escherichia albertii]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCACCCAACCACCCGCCGCCGAAGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCAGGAGTTTATTGGGGTAATTAC
AGGTAAACAGAAAGTCGCCTGA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16750.08 Da
• Isoelectric Point: 6.6451

>AT203117 WP_001259012.1 NZ_CP075127:4560378-4560824 [Salmonella enterica]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKSLN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Nucleotide

• Length: 447 bp

>AT203117 NZ_CP099880:c4093374-4093298 [Escherichia albertii]
AGTCATGATTACTATTCTCCAGAAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: A0A0R9ME90