Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/Tad-HTH_37 |
| Location | 2697795..2698323 | Replicon | chromosome |
| Accession | NZ_CP075127 | ||
| Organism | Salmonella enterica strain CFSAN044925 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | A7S47_RS23080 | Protein ID | WP_108429764.1 |
| Coordinates | 2697795..2698025 (+) | Length | 77 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | A7S47_RS23085 | Protein ID | WP_000147078.1 |
| Coordinates | 2698015..2698323 (+) | Length | 103 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| A7S47_RS13155 (2693030) | 2693030..2693230 | + | 201 | WP_033578003.1 | phage virulence factor PagK family protein | - |
| A7S47_RS13160 (2693327) | 2693327..2693737 | - | 411 | WP_001525515.1 | tail fiber assembly protein | - |
| A7S47_RS13165 (2693744) | 2693744..2693842 | - | 99 | Protein_2591 | phage tail protein | - |
| A7S47_RS13170 (2693844) | 2693844..2695166 | - | 1323 | Protein_2592 | DNA circularization N-terminal domain-containing protein | - |
| A7S47_RS13175 (2695200) | 2695200..2695601 | - | 402 | WP_001525519.1 | hypothetical protein | - |
| A7S47_RS13180 (2695607) | 2695607..2695882 | - | 276 | Protein_2594 | phage tail tube protein | - |
| A7S47_RS13185 (2695882) | 2695882..2696097 | - | 216 | Protein_2595 | phage tail protein | - |
| A7S47_RS13190 (2696090) | 2696090..2696614 | - | 525 | Protein_2596 | helix-turn-helix domain-containing protein | - |
| A7S47_RS13195 (2696611) | 2696611..2696835 | - | 225 | WP_000620702.1 | hypothetical protein | - |
| A7S47_RS23075 (2696832) | 2696832..2697830 | - | 999 | WP_237703493.1 | Rha family phage regulatory protein | - |
| A7S47_RS23080 (2697795) | 2697795..2698025 | + | 231 | WP_108429764.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| A7S47_RS23085 (2698015) | 2698015..2698323 | + | 309 | WP_000147078.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| A7S47_RS23090 (2698342) | 2698342..2698518 | - | 177 | WP_001525520.1 | DUF4222 domain-containing protein | - |
| A7S47_RS13205 (2698658) | 2698658..2699212 | - | 555 | WP_000509733.1 | YmfL family putative regulatory protein | - |
| A7S47_RS13210 (2699241) | 2699241..2699465 | - | 225 | WP_001191666.1 | helix-turn-helix transcriptional regulator | - |
| A7S47_RS13215 (2699563) | 2699563..2700258 | + | 696 | WP_058671845.1 | helix-turn-helix transcriptional regulator | - |
| A7S47_RS13220 (2700467) | 2700467..2700775 | + | 309 | WP_023262052.1 | hypothetical protein | - |
| A7S47_RS13225 (2700713) | 2700713..2701051 | - | 339 | WP_071586821.1 | hypothetical protein | - |
| A7S47_RS23095 (2701248) | 2701248..2701379 | + | 132 | Protein_2607 | hypothetical protein | - |
| A7S47_RS13230 (2701419) | 2701419..2701655 | + | 237 | Protein_2608 | hypothetical protein | - |
| A7S47_RS13235 (2701713) | 2701713..2702540 | + | 828 | WP_001525327.1 | DUF2303 family protein | - |
| A7S47_RS13240 (2702677) | 2702677..2703216 | + | 540 | WP_000008352.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | sopE2 / sspH1 | 2662709..2704727 | 42018 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 77 a.a. Molecular weight: 8640.11 Da Isoelectric Point: 10.5308
>T203109 WP_108429764.1 NZ_CP075127:2697795-2698025 [Salmonella enterica]
MKVYGSNLGEPHTSAFGDGLFELRIKGSDGIARVFYCTLAGKRIVMLHSFIKKTQKTPVAERKKAETRMKEVKHDW
MKVYGSNLGEPHTSAFGDGLFELRIKGSDGIARVFYCTLAGKRIVMLHSFIKKTQKTPVAERKKAETRMKEVKHDW
Download Length: 231 bp
>T203109 NZ_CP099880:2146121-2146223 [Escherichia albertii]
GCAAGGCAACTGAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAAAACA
GGAATCGTTTTCGGTCTCTTTTT
GCAAGGCAACTGAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAAAACA
GGAATCGTTTTCGGTCTCTTTTT
Antitoxin
Download Length: 103 a.a. Molecular weight: 11110.77 Da Isoelectric Point: 7.0152
>AT203109 WP_000147078.1 NZ_CP075127:2698015-2698323 [Salmonella enterica]
MTGKRNAPTITHDEMAAKWMEDPAFKAEYDAIADEFALLDEMLAARKEAGLTQAEVAERMGTKATAITRMESNLAAGVSG
PSFTTLKKFAQATGKKLQIRFV
MTGKRNAPTITHDEMAAKWMEDPAFKAEYDAIADEFALLDEMLAARKEAGLTQAEVAERMGTKATAITRMESNLAAGVSG
PSFTTLKKFAQATGKKLQIRFV
Download Length: 309 bp
>AT203109 NZ_CP099880:c2146225-2145993 [Escherichia albertii]
ATAAAAAGAGACCGAAAACGATTCCTGTTTTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTCAGTTGCCTTGCTCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCGTACAAAATGGTCAG
TAAAAAGCGCGTCGGCCATCGTCTTAAATGTTAAAAACCGCCCGTTCTGGTGAAAGAACTGTGGCGGTTTTTT
ATAAAAAGAGACCGAAAACGATTCCTGTTTTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTCAGTTGCCTTGCTCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCGTACAAAATGGTCAG
TAAAAAGCGCGTCGGCCATCGTCTTAAATGTTAAAAACCGCCCGTTCTGGTGAAAGAACTGTGGCGGTTTTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|