Detailed information of TA system TA203094

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 4686549..4687303
• Replicon: chromosome
• Accession: NZ_CP075125
• Organism: Salmonella enterica strain CFSAN044945

Toxin (Protein)

• Gene name: higB
• Uniprot ID: B5F003
• Locus tag: A7S67_RS22700
• Protein ID: WP_000558166.1
• Coordinates: 4686549..4686860 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: A7S67_RS22705
• Protein ID: WP_001259011.1
• Coordinates: 4686857..4687303 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7S67_RS22670 (4682207)	4682207..4683109	+	903	WP_000331361.1	formate dehydrogenase subunit beta	-
A7S67_RS22675 (4683106)	4683106..4683741	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
A7S67_RS22680 (4683738)	4683738..4684667	+	930	WP_070794361.1	formate dehydrogenase accessory protein FdhE	-
A7S67_RS22685 (4684714)	4684714..4685004	-	291	WP_000362050.1	DNA-binding transcriptional regulator	-
A7S67_RS22690 (4685005)	4685005..4685316	-	312	WP_001159631.1	cytotoxic translational repressor of toxin-antitoxin stability system	-
A7S67_RS22695 (4685534)	4685534..4686463	+	930	WP_001646963.1	alpha/beta hydrolase	-
A7S67_RS22700 (4686549)	4686549..4686860	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	Toxin
A7S67_RS22705 (4686857)	4686857..4687303	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	Antitoxin
A7S67_RS22710 (4687318)	4687318..4688259	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
A7S67_RS22715 (4688304)	4688304..4688741	-	438	WP_000560969.1	D-aminoacyl-tRNA deacylase	-
A7S67_RS22720 (4688738)	4688738..4689610	-	873	WP_000921423.1	virulence factor BrkB family protein	-
A7S67_RS22725 (4689604)	4689604..4690203	-	600	WP_001646959.1	glucose-1-phosphatase	-
A7S67_RS22730 (4690394)	4690394..4691197	-	804	WP_023137059.1	DeoR/GlpR family DNA-binding transcription regulator	-
A7S67_RS22735 (4691231)	4691231..4692127	-	897	WP_001520529.1	sugar kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, mRNA interferase HigB (21-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (93-146)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12432.40 Da
• Isoelectric Point: 9.5334

>T203094 WP_000558166.1 NZ_CP075125:4686549-4686860 [Salmonella enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Nucleotide

• Length: 312 bp

>T203094 NZ_CP099877:2117012-2117115 [Escherichia albertii]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAAAAC
AGGAATCGTTTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16734.08 Da
• Isoelectric Point: 6.6451

>AT203094 WP_001259011.1 NZ_CP075125:4686857-4687303 [Salmonella enterica]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Nucleotide

• Length: 447 bp

>AT203094 NZ_CP099877:c2117117-2116885 [Escherichia albertii]
ATAAAAAGAGACCGAAAACGATTCCTGTTTTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCGTACAAAATGGTCAG
TAAAAAGCGCGTCGGCCATCGTCTTAAATGTTAAAAACCGCCCGTTCTGGTGAAAGAACTGTGGCGGTTTTTT

Structures

Toxin

• AlphaFold DB: A0A0R9ME90