Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4684714..4685316 Replicon chromosome
Accession NZ_CP075125
Organism Salmonella enterica strain CFSAN044945

Toxin (Protein)


Gene name higB Uniprot ID A0A3V8XMR3
Locus tag A7S67_RS22690 Protein ID WP_001159631.1
Coordinates 4685005..4685316 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag A7S67_RS22685 Protein ID WP_000362050.1
Coordinates 4684714..4685004 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7S67_RS22670 (4682207) 4682207..4683109 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
A7S67_RS22675 (4683106) 4683106..4683741 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
A7S67_RS22680 (4683738) 4683738..4684667 + 930 WP_070794361.1 formate dehydrogenase accessory protein FdhE -
A7S67_RS22685 (4684714) 4684714..4685004 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
A7S67_RS22690 (4685005) 4685005..4685316 - 312 WP_001159631.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
A7S67_RS22695 (4685534) 4685534..4686463 + 930 WP_001646963.1 alpha/beta hydrolase -
A7S67_RS22700 (4686549) 4686549..4686860 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
A7S67_RS22705 (4686857) 4686857..4687303 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
A7S67_RS22710 (4687318) 4687318..4688259 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
A7S67_RS22715 (4688304) 4688304..4688741 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
A7S67_RS22720 (4688738) 4688738..4689610 - 873 WP_000921423.1 virulence factor BrkB family protein -
A7S67_RS22725 (4689604) 4689604..4690203 - 600 WP_001646959.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12312.25 Da        Isoelectric Point: 9.4460

>T203093 WP_001159631.1 NZ_CP075125:c4685316-4685005 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEVRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

>T203093 NZ_CP099877:1093773-1093925 [Escherichia albertii]
ATGCTGACAAAATATGCCCTTGTGGCAATCATCGTACTGTGTTGTACAGTACTGGGATTCACGCTGATGGTAGGCGACTC
GTTGTGTGAGTTGAGTATCAGAGAACGTGGTATGGAGTTTAAGGCAGTTCTCGCTTACGAATCGAAGAAGTAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT203093 WP_000362050.1 NZ_CP075125:c4685004-4684714 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp

>AT203093 NZ_CP099877:c1093728-1093680 [Escherichia albertii]
GTTCGAACGTAGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V8XMR3

Antitoxin

Source ID Structure

References