203075

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4490149..4490903 Replicon chromosome
Accession NZ_CP075122
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain CFSAN051827

Toxin (Protein)


Gene name higB Uniprot ID B5RFE2
Locus tag BCA48_RS21665 Protein ID WP_000558168.1
Coordinates 4490149..4490460 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag BCA48_RS21670 Protein ID WP_001259009.1
Coordinates 4490457..4490903 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCA48_RS21635 (4485807) 4485807..4486709 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
BCA48_RS21640 (4486706) 4486706..4487341 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
BCA48_RS21645 (4487338) 4487338..4488267 + 930 WP_000027736.1 formate dehydrogenase accessory protein FdhE -
BCA48_RS21650 (4488314) 4488314..4488604 - 291 WP_000362050.1 DNA-binding transcriptional regulator -
BCA48_RS21655 (4488605) 4488605..4488916 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system -
BCA48_RS21660 (4489134) 4489134..4490063 + 930 WP_001127705.1 alpha/beta hydrolase -
BCA48_RS21665 (4490149) 4490149..4490460 + 312 WP_000558168.1 type II toxin-antitoxin system HigB family toxin Toxin
BCA48_RS21670 (4490457) 4490457..4490903 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
BCA48_RS21675 (4490918) 4490918..4491859 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
BCA48_RS21680 (4491904) 4491904..4492341 - 438 WP_000560968.1 D-aminoacyl-tRNA deacylase -
BCA48_RS21685 (4492338) 4492338..4493210 - 873 WP_000921423.1 virulence factor BrkB family protein -
BCA48_RS21690 (4493204) 4493204..4493803 - 600 WP_000965695.1 glucose-1-phosphatase -
BCA48_RS21695 (4493994) 4493994..4494797 - 804 WP_000059693.1 DeoR/GlpR family DNA-binding transcription regulator -
BCA48_RS21700 (4494831) 4494831..4495727 - 897 WP_001520529.1 sugar kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(93-146)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12324.26 Da        Isoelectric Point: 9.3143

>T203075 WP_000558168.1 NZ_CP075122:4490149-4490460 [Salmonella enterica subsp. enterica serovar Enteritidis]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTLTQPEEMKRYIPSLDNFKHRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYDRGNKE

Download         Length: 312 bp

>T203075 NZ_CP099874:1093975-1094127 [Escherichia albertii]
ATGCTGACAAAATATGCCCTTGTGGCAATCATCGTACTGTGTTGTACAGTACTGGGATTCACGCTGATGGTAGGCGACTC
GTTGTGTGAGTTGAGTATCAGAGAACGTGGTATGGAGTTTAAGGCAGTTCTCGCTTACGAATCGAAGAAGTAG

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16720.06 Da        Isoelectric Point: 6.6451

>AT203075 WP_001259009.1 NZ_CP075122:4490457-4490903 [Salmonella enterica subsp. enterica serovar Enteritidis]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT203075 NZ_CP099874:c1093930-1093882 [Escherichia albertii]
GTTCGAACGTAGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1R2S541

Antitoxin

Source ID Structure

References