Detailed information of TA system TA203074

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4488314..4488916
• Replicon: chromosome
• Accession: NZ_CP075122
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain CFSAN051827

Toxin (Protein)

• Gene name: higB
• Uniprot ID: M7S4R6
• Locus tag: BCA48_RS21655
• Protein ID: WP_001159635.1
• Coordinates: 4488605..4488916 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: BCA48_RS21650
• Protein ID: WP_000362050.1
• Coordinates: 4488314..4488604 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BCA48_RS21635 (4485807)	4485807..4486709	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
BCA48_RS21640 (4486706)	4486706..4487341	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
BCA48_RS21645 (4487338)	4487338..4488267	+	930	WP_000027736.1	formate dehydrogenase accessory protein FdhE	-
BCA48_RS21650 (4488314)	4488314..4488604	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
BCA48_RS21655 (4488605)	4488605..4488916	-	312	WP_001159635.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
BCA48_RS21660 (4489134)	4489134..4490063	+	930	WP_001127705.1	alpha/beta hydrolase	-
BCA48_RS21665 (4490149)	4490149..4490460	+	312	WP_000558168.1	type II toxin-antitoxin system HigB family toxin	-
BCA48_RS21670 (4490457)	4490457..4490903	+	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	-
BCA48_RS21675 (4490918)	4490918..4491859	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
BCA48_RS21680 (4491904)	4491904..4492341	-	438	WP_000560968.1	D-aminoacyl-tRNA deacylase	-
BCA48_RS21685 (4492338)	4492338..4493210	-	873	WP_000921423.1	virulence factor BrkB family protein	-
BCA48_RS21690 (4493204)	4493204..4493803	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12340.30 Da
• Isoelectric Point: 9.4460

>T203074 WP_001159635.1 NZ_CP075122:c4488916-4488605 [Salmonella enterica subsp. enterica serovar Enteritidis]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T203074 NZ_CP099874:930608-931012 [Escherichia albertii]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTCTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGCTATTTTACTCATGCCCTGGCCGCTAAGTTATACCCCGTTATGGATGGTGTTGCTTTCGCTGGTGGTGTTTGATTGCG
TCCGCAGTCAGCGGCGCATTAATGCTCGTCAGGGGGAGATTCGCCTGTTGATGGATGGGCGTTTACGCTGGCAGGGGCAG
GAGTGGAGCATCGTCAGAGCGCCGTGGATGATTAAAACTGGCATGATGTTGCGTTTACTCTCTGATAGCGGCAAACGTCA
GCACCTGTGGCTGGCAGCCGACAGTATGGATGAAGCTGAATGGCGGGATTTGCGGCGAATTTTGTTACAACAAGAGATAC
AGTGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT203074 WP_000362050.1 NZ_CP075122:c4488604-4488314 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT203074 NZ_CP099874:930361-930627 [Escherichia albertii]
ATGGACATTAACAATAAAGCCCGCATTCACTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGATAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGACTGCTGGAATGTGACGATCCCGATT
TATTCAACTGGTTGATGAATCACGGTAAACCGGCCGACGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: A0A3V2JK97