Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4489749..4490503 Replicon chromosome
Accession NZ_CP075120
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain CFSAN051882

Toxin (Protein)


Gene name higB Uniprot ID B5RFE2
Locus tag BCB01_RS21665 Protein ID WP_000558168.1
Coordinates 4489749..4490060 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag BCB01_RS21670 Protein ID WP_001259009.1
Coordinates 4490057..4490503 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCB01_RS21635 (4485407) 4485407..4486309 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
BCB01_RS21640 (4486306) 4486306..4486941 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
BCB01_RS21645 (4486938) 4486938..4487867 + 930 WP_000027736.1 formate dehydrogenase accessory protein FdhE -
BCB01_RS21650 (4487914) 4487914..4488204 - 291 WP_000362050.1 DNA-binding transcriptional regulator -
BCB01_RS21655 (4488205) 4488205..4488516 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system -
BCB01_RS21660 (4488734) 4488734..4489663 + 930 WP_001127705.1 alpha/beta hydrolase -
BCB01_RS21665 (4489749) 4489749..4490060 + 312 WP_000558168.1 type II toxin-antitoxin system HigB family toxin Toxin
BCB01_RS21670 (4490057) 4490057..4490503 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
BCB01_RS21675 (4490518) 4490518..4491459 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
BCB01_RS21680 (4491504) 4491504..4491941 - 438 WP_000560968.1 D-aminoacyl-tRNA deacylase -
BCB01_RS21685 (4491938) 4491938..4492810 - 873 WP_000921423.1 virulence factor BrkB family protein -
BCB01_RS21690 (4492804) 4492804..4493403 - 600 WP_000965695.1 glucose-1-phosphatase -
BCB01_RS21695 (4493594) 4493594..4494397 - 804 WP_000059693.1 DeoR/GlpR family DNA-binding transcription regulator -
BCB01_RS21700 (4494431) 4494431..4495327 - 897 WP_001520529.1 sugar kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(93-146)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12324.26 Da        Isoelectric Point: 9.3143

>T203048 WP_000558168.1 NZ_CP075120:4489749-4490060 [Salmonella enterica subsp. enterica serovar Enteritidis]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTLTQPEEMKRYIPSLDNFKHRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYDRGNKE

Download         Length: 312 bp

>T203048 NZ_CP099868:4011620-4011772 [Escherichia albertii]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16720.06 Da        Isoelectric Point: 6.6451

>AT203048 WP_001259009.1 NZ_CP075120:4490057-4490503 [Salmonella enterica subsp. enterica serovar Enteritidis]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT203048 NZ_CP099868:c4011571-4011514 [Escherichia albertii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1R2S541

Antitoxin

Source ID Structure

References