Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 4489749..4490503 | Replicon | chromosome |
Accession | NZ_CP075120 | ||
Organism | Salmonella enterica subsp. enterica serovar Enteritidis strain CFSAN051882 |
Toxin (Protein)
Gene name | higB | Uniprot ID | B5RFE2 |
Locus tag | BCB01_RS21665 | Protein ID | WP_000558168.1 |
Coordinates | 4489749..4490060 (+) | Length | 104 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | BCB01_RS21670 | Protein ID | WP_001259009.1 |
Coordinates | 4490057..4490503 (+) | Length | 149 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
BCB01_RS21635 (4485407) | 4485407..4486309 | + | 903 | WP_000331364.1 | formate dehydrogenase subunit beta | - |
BCB01_RS21640 (4486306) | 4486306..4486941 | + | 636 | WP_000829025.1 | formate dehydrogenase cytochrome b556 subunit | - |
BCB01_RS21645 (4486938) | 4486938..4487867 | + | 930 | WP_000027736.1 | formate dehydrogenase accessory protein FdhE | - |
BCB01_RS21650 (4487914) | 4487914..4488204 | - | 291 | WP_000362050.1 | DNA-binding transcriptional regulator | - |
BCB01_RS21655 (4488205) | 4488205..4488516 | - | 312 | WP_001159635.1 | cytotoxic translational repressor of toxin-antitoxin stability system | - |
BCB01_RS21660 (4488734) | 4488734..4489663 | + | 930 | WP_001127705.1 | alpha/beta hydrolase | - |
BCB01_RS21665 (4489749) | 4489749..4490060 | + | 312 | WP_000558168.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
BCB01_RS21670 (4490057) | 4490057..4490503 | + | 447 | WP_001259009.1 | type II toxin-antitoxin system HigA family antitoxin | Antitoxin |
BCB01_RS21675 (4490518) | 4490518..4491459 | - | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
BCB01_RS21680 (4491504) | 4491504..4491941 | - | 438 | WP_000560968.1 | D-aminoacyl-tRNA deacylase | - |
BCB01_RS21685 (4491938) | 4491938..4492810 | - | 873 | WP_000921423.1 | virulence factor BrkB family protein | - |
BCB01_RS21690 (4492804) | 4492804..4493403 | - | 600 | WP_000965695.1 | glucose-1-phosphatase | - |
BCB01_RS21695 (4493594) | 4493594..4494397 | - | 804 | WP_000059693.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
BCB01_RS21700 (4494431) | 4494431..4495327 | - | 897 | WP_001520529.1 | sugar kinase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12324.26 Da Isoelectric Point: 9.3143
>T203048 WP_000558168.1 NZ_CP075120:4489749-4490060 [Salmonella enterica subsp. enterica serovar Enteritidis]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTLTQPEEMKRYIPSLDNFKHRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYDRGNKE
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTLTQPEEMKRYIPSLDNFKHRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYDRGNKE
Download Length: 312 bp
>T203048 NZ_CP099868:4011620-4011772 [Escherichia albertii]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA
Antitoxin
Download Length: 149 a.a. Molecular weight: 16720.06 Da Isoelectric Point: 6.6451
>AT203048 WP_001259009.1 NZ_CP075120:4490057-4490503 [Salmonella enterica subsp. enterica serovar Enteritidis]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
Download Length: 447 bp
>AT203048 NZ_CP099868:c4011571-4011514 [Escherichia albertii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|