Detailed information of TA system TA203047

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4487914..4488516
• Replicon: chromosome
• Accession: NZ_CP075120
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain CFSAN051882

Toxin (Protein)

• Gene name: higB
• Uniprot ID: M7S4R6
• Locus tag: BCB01_RS21655
• Protein ID: WP_001159635.1
• Coordinates: 4488205..4488516 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: BCB01_RS21650
• Protein ID: WP_000362050.1
• Coordinates: 4487914..4488204 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BCB01_RS21635 (4485407)	4485407..4486309	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
BCB01_RS21640 (4486306)	4486306..4486941	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
BCB01_RS21645 (4486938)	4486938..4487867	+	930	WP_000027736.1	formate dehydrogenase accessory protein FdhE	-
BCB01_RS21650 (4487914)	4487914..4488204	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
BCB01_RS21655 (4488205)	4488205..4488516	-	312	WP_001159635.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
BCB01_RS21660 (4488734)	4488734..4489663	+	930	WP_001127705.1	alpha/beta hydrolase	-
BCB01_RS21665 (4489749)	4489749..4490060	+	312	WP_000558168.1	type II toxin-antitoxin system HigB family toxin	-
BCB01_RS21670 (4490057)	4490057..4490503	+	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	-
BCB01_RS21675 (4490518)	4490518..4491459	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
BCB01_RS21680 (4491504)	4491504..4491941	-	438	WP_000560968.1	D-aminoacyl-tRNA deacylase	-
BCB01_RS21685 (4491938)	4491938..4492810	-	873	WP_000921423.1	virulence factor BrkB family protein	-
BCB01_RS21690 (4492804)	4492804..4493403	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12340.30 Da
• Isoelectric Point: 9.4460

>T203047 WP_001159635.1 NZ_CP075120:c4488516-4488205 [Salmonella enterica subsp. enterica serovar Enteritidis]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T203047 NZ_CP099868:c3710646-3710305 [Escherichia albertii]
ATGTGGGACGTCGAGACAACGGAGACTTTCGACAACTGGTTTGATGCCCAGACTGTTGCGCTGAAAGAAGATTTGCTTGC
TGCAATGCTGATTCTTGCAGAGTATGGCCCACAGTTGGGCAGGCCCTTTGCGGACACGGTTAATGATTCACAGTTTTCAA
ATATGAAAGAATTACGCGTCCAACATCAGGGAAACCCGGTACGTGCTTTTTTTGCTTTCGATCCTGCGCGCCGTGGCATT
GTATTATGTGCAGGTGATAAAACGGGGTTAAATGAGAAAAAGTTTTATCGCGATATGATCAAGCTCGCTGATTCTGAATA
CCGTAATCATCTGAAAAAGTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT203047 WP_000362050.1 NZ_CP075120:c4488204-4487914 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT203047 NZ_CP099868:c3710295-3709996 [Escherichia albertii]
ATGGCTACTCTAAAAGAACTGATGGCAAAGCAAAGCCCTGAAAGCCAGGCGCGTATTGCGGCAAAAGTTGAGGAAATGCG
CCAGACCATCGCCTTGCATCAGCTGAGAGAAGAACTCAATATTTCGCAAACGGAAATGGCGGCAGCGATGGGCATTAAGC
AACCGACCCTTGCAAAAATGGAGCAGGCAGATAACGATCCTCGGTTGTCTACGCTAAAACGCTATGTCGCGGCTTTAGGT
GGGGAATTGAGTATCGACGTTAAACTGCCTAATGGTAAGAGAGTTGCATTTCAGATTTAA

Structures

Toxin

• AlphaFold DB: A0A3V2JK97