Detailed information of TA system TA203002

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2437532..2437757
• Replicon: chromosome
• Accession: NZ_CP075118
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain CFSAN051890

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: BCB09_RS11765
• Protein ID: WP_000813254.1
• Coordinates: 2437532..2437687 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2437699..2437757 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BCB09_RS11730	2432639..2432920	-	282	WP_000445513.1	phage holin family protein	-
BCB09_RS11735	2432910..2433098	-	189	WP_001688615.1	putative holin	-
BCB09_RS11740	2433092..2433415	-	324	Protein_2311	tellurite/colicin resistance protein	-
BCB09_RS11745	2435586..2436122	-	537	WP_000640113.1	DUF1133 family protein	-
BCB09_RS11750	2436119..2436409	-	291	WP_000774470.1	DUF1364 domain-containing protein	-
BCB09_RS11755	2436409..2437008	-	600	WP_000940751.1	DUF1367 family protein	-
BCB09_RS11760	2437071..2437241	-	171	WP_000734094.1	hypothetical protein	-
BCB09_RS11765	2437532..2437687	-	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
-	2437699..2437757	+	59	-	-	Antitoxin
BCB09_RS11770	2438114..2439046	+	933	WP_000556389.1	hypothetical protein	-
BCB09_RS11775	2439043..2439597	+	555	WP_001033796.1	hypothetical protein	-
BCB09_RS11780	2439759..2440088	-	330	WP_001676916.1	DUF977 family protein	-
BCB09_RS23115	2440132..2440179	-	48	Protein_2320	hypothetical protein	-
BCB09_RS11790	2440361..2440828	+	468	WP_001227859.1	helix-turn-helix domain-containing protein	-
BCB09_RS11795	2441213..2441368	+	156	WP_085981757.1	DUF1391 family protein	-
BCB09_RS11800	2441476..2441997	-	522	WP_000004762.1	super-infection exclusion protein B	-
BCB09_RS11805	2442435..2442656	+	222	WP_000560208.1	cell division protein FtsZ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2432097..2443968	11871

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T203002 WP_000813254.1 NZ_CP075118:c2437687-2437532 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T203002 NZ_CP099811:c3153014-3152694 [Yersinia ruckeri]
ATGCAAACCACAACTGTACCGGCCACGTTGCCGGTTTCATCACGCCAGTCTCCCGTCCAGGTGTGGCAACAACTGTTAAC
GTATCTACTGGAACACCATTACGGCCTGACGCTTAACGATACGCCATTTCATGATGACGCATCCATAGAGGAACATATCG
AAGCGGGAATAACGCTTGCTGATGCAGTGAATTTCCTGGTTGAACGCTATGAGCTGGTGCGCACTGACCGCAAAGGATTC
ACTTGGCAGGAGCAAACCCCATTTCTGACCGCTACAGATATTCTCAGAGCAAAGCGGGCTACCGGATTAATGAATACGTA
A

Antitoxin

Nucleotide

• Length: 59 bp

>AT203002 NZ_CP075118:2437699-2437757 [Salmonella enterica subsp. enterica serovar Enteritidis]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin