Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4497793..4498547 Replicon chromosome
Accession NZ_CP075116
Organism Salmonella enterica subsp. enterica serovar Stanleyville strain CFSAN059881

Toxin (Protein)


Gene name higB Uniprot ID A0A5I4V816
Locus tag CCO40_RS21470 Protein ID WP_017465947.1
Coordinates 4497793..4498104 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CCO40_RS21475 Protein ID WP_017465948.1
Coordinates 4498101..4498547 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCO40_RS21440 (4493451) 4493451..4494353 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
CCO40_RS21445 (4494350) 4494350..4494985 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
CCO40_RS21450 (4494982) 4494982..4495911 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
CCO40_RS21455 (4495958) 4495958..4496248 - 291 WP_000362050.1 DNA-binding transcriptional regulator -
CCO40_RS21460 (4496249) 4496249..4496560 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system -
CCO40_RS21465 (4496778) 4496778..4497707 + 930 WP_001127703.1 alpha/beta hydrolase -
CCO40_RS21470 (4497793) 4497793..4498104 + 312 WP_017465947.1 type II toxin-antitoxin system HigB family toxin Toxin
CCO40_RS21475 (4498101) 4498101..4498547 + 447 WP_017465948.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
CCO40_RS21480 (4498562) 4498562..4499503 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
CCO40_RS21485 (4499548) 4499548..4499985 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
CCO40_RS21490 (4499982) 4499982..4500854 - 873 WP_000921423.1 virulence factor BrkB family protein -
CCO40_RS21495 (4500848) 4500848..4501447 - 600 WP_000965695.1 glucose-1-phosphatase -
CCO40_RS21500 (4501638) 4501638..4502441 - 804 WP_001728053.1 DeoR/GlpR family DNA-binding transcription regulator -
CCO40_RS21505 (4502475) 4502475..4503371 - 897 WP_001805206.1 sugar kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(93-146)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12384.31 Da        Isoelectric Point: 9.2528

>T202995 WP_017465947.1 NZ_CP075116:4497793-4498104 [Salmonella enterica subsp. enterica serovar Stanleyville]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYDRGNKE

Download         Length: 312 bp

>T202995 NZ_CP099809:c3155647-3154991 [Yersinia ruckeri]
GTGGCCTATGACTACAGCACTAGCCTCAACCCGGAAAAAGCCTTGATCTGGCGCATTGTCCATCGGGACAATATTCCGTG
GATACTGGACAACGGTCTGCACTGTGGCAACAGTCCGGTGCAGGCGGAAGACTGGATTAATATCGGTAACCCGGAGCTTA
TCGACAAACGTGCCGGACATCTGGTGCCAACCGGAATGCGGGGGACGCTGCATGACTATGTGCCGTTTTACTTTACTCCT
TTCTCGCCGATGCTGATGAATATCCGCAGCGGACGTGGCGGCATTAAGCAACGCCCCAATGAGGAGATCGTTATTCTGGT
CAGTAGCCTGCGAAACATGGTGGCGCAAAATGTCTCCTTCGTGTTTACCGATAGCCACGCATATTATAACCTGGCTAATT
ACTTTACCGAGCTGGACAGTCTGAACCAGATCGATTGGCCCATTCTACAAGCGCGGGATTTCCGTCGCGATCAGGACGAT
TTGGCCAAGTTCGAACGCTATCAGGCAGAGGCGTTAATTTGGAAGCACTGCCCAATAGCGCTGCTTGGCGGGATGATTTG
TTACAACGATGGCGTCAGGTTACAATTAGAGCAGTGGTTGTCGCAACGCAATCTGTCAATGCCCGTTCACGCGCGGGCTG
GGTGGTACTTCTCATGA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16736.06 Da        Isoelectric Point: 6.6451

>AT202995 WP_017465948.1 NZ_CP075116:4498101-4498547 [Salmonella enterica subsp. enterica serovar Stanleyville]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKSLN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT202995 NZ_CP099809:c3154994-3153927 [Yersinia ruckeri]
ATGATTACATTTACACAAGGCAATTTACTGGATGCGCCCGTAGAAGCACTAGTGAATACGGTTAATACCGTCGGTGTCAT
GGGTAAAGGCATCGCGCTGATGTTCAAAGAGCGCTTCCCCGTCAATATGAAAGCCTATGCTCTCGCCTGCAAACATAAGC
AGGTAATGACAGGTAAAATGTTTATTACCGAAACCGGCGAACTGATGGGGCCTCGCTGGATTGTCAACTTCCCAACTAAA
CAACACTGGCGCGCAGACTCCCGCATGGAGTGGGTTGAAGACGGCTTGCAGGATTTACGCCGCTTTTTGATCGAAGAGAA
AGTGCAATCTATCGCCATTCCCCCACTGGGGGCGGGTAACGGCGGCCTGAATTGGTCGGACGTTCGGATGCGGATTGAAT
CTGCGCTGGGCGACCTTCAGGACACGGAAATTCTGATTTATGAGCCTACCGAAAAATACCAGAACGTCGCCAAGAGCACC
GGCGTAAAAAAGCTCACTCCCGCCAGAGCGCTGATTGCTGAACTGGTGCGCCGCTACTGGGTGCTGGGCATGGAGTGCAG
CCTGCTGGAAATCCAGAAGCTGGCATGGCTGTTACAACGCGCCATTGAACAGCATCAGCAGGAAGATGTGCTGAAACTGC
GGTTTGAGGCGCACTATTACGGCCCCTACGCCCCCAACCTTAACCATCTGCTTAACGCGCTAGATGGCACGTATCTGAAA
GCAGAGAAACGCATCCCGGACACCCAGCCGCTGGATGTGATCTGGTTTAATGATCAGGAAAAAGAACACATCAACCTCTG
GCTGAACAACGAGGCCAAAGAGTGGCTACCGGCGCTTGAGCAGGTCAGTCAGTTGATTGACGGCTTTGAATCGCCGTTTG
GTCTGGAGCTGCTGGCAACCGTTGACTGGCTGCTGACCCGAGGAAAATGCCAGCCCACGCTGGATTCCGTGAAAGAGGGG
CTGCACCAGTGGCCTGCGGGTGAACGCTGGGCCAGCCGTAAGATGAAGCTCTTTGACGACAAGAATCTGCAATTTGCCAT
CAACCGCGTGATGGAGTTCCATTGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I4V816

Antitoxin

Source ID Structure

References