Detailed information of TA system TA202994

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4495958..4496560
• Replicon: chromosome
• Accession: NZ_CP075116
• Organism: Salmonella enterica subsp. enterica serovar Stanleyville strain CFSAN059881

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0Q3J8
• Locus tag: CCO40_RS21460
• Protein ID: WP_001159630.1
• Coordinates: 4496249..4496560 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: CCO40_RS21455
• Protein ID: WP_000362050.1
• Coordinates: 4495958..4496248 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCO40_RS21440 (4493451)	4493451..4494353	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
CCO40_RS21445 (4494350)	4494350..4494985	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
CCO40_RS21450 (4494982)	4494982..4495911	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
CCO40_RS21455 (4495958)	4495958..4496248	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
CCO40_RS21460 (4496249)	4496249..4496560	-	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
CCO40_RS21465 (4496778)	4496778..4497707	+	930	WP_001127703.1	alpha/beta hydrolase	-
CCO40_RS21470 (4497793)	4497793..4498104	+	312	WP_017465947.1	type II toxin-antitoxin system HigB family toxin	-
CCO40_RS21475 (4498101)	4498101..4498547	+	447	WP_017465948.1	type II toxin-antitoxin system HigA family antitoxin	-
CCO40_RS21480 (4498562)	4498562..4499503	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
CCO40_RS21485 (4499548)	4499548..4499985	-	438	WP_000560969.1	D-aminoacyl-tRNA deacylase	-
CCO40_RS21490 (4499982)	4499982..4500854	-	873	WP_000921423.1	virulence factor BrkB family protein	-
CCO40_RS21495 (4500848)	4500848..4501447	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12326.27 Da
• Isoelectric Point: 9.4460

>T202994 WP_001159630.1 NZ_CP075116:c4496560-4496249 [Salmonella enterica subsp. enterica serovar Stanleyville]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T202994 NZ_CP099809:c3151815-3150865 [Yersinia ruckeri]
ATGGATGATTTAACAAAGCTATTCCCAGATGTTGCTGATGCTCTGGGCATTGAATCTGTTTCAATTGTAGAAAAAGATTA
TTACATCGTTGAGTTATTACGATTGCTCCAGCCTATGGACTTTGACACGCATCAGCTGGTTTTTGCCGGTGGAACAGCAT
TGTCAAAAGCGGGTATATCTTTGAACAGGATGTCGGAAGACGTGGACATTAAGCTTGTCCCCGTCGCTGGTTTTACCCAG
CAATATTCCAGAGGCCAGCGTAAAGACATTCGTAAGGGTATTATTCGGACCGTTATCGAAACGATTACAGCTTCAGGTAC
GTTTCGCATGGATGAAGGGTATCCAAAGGTTACTCGTGATGAATATCGCTATAATGAAATTCCGGTGCGTTACCCGCAGG
AATATGTACAAGTTCCCTGCTTAAGGCCATTTATCAAACTGGAACTGATGGAAACGGATTTGCTTGAGGCTGCGGAAAAT
CGTGCTATTAGCTCCTTGGTAATGGATCTAACAAAGAAGGGCGAAGTAGTGAGGGCTTTCCCTTGCGCAACCATCGGTAG
CACGCAGGCTGAAAAACTGATCTCGATGATGCGCAGAACGGCTGCAAGTATGCGTGATGTGGAACGTGCAGTGGATGAAT
CACTGGTACGTCATATCTACGATAATTTTTGTATTGTTAGAGAAAAAGGTGCTGACGTTCCTGTTTTGAAGCAATTCGTG
CAGGAATGCATTGAACAGGATATTGAACGTTACGGTGCTCAGTACCCTGAATTCTGCGAGTCGCCTGTCGAAGAACTAAA
AATGGGGCTGGAAGAACTCGTGAGCAATCCTGTTTATAAGGAACGCTATCTGCAATTCGTCACACCAATGGTCTTCGGTG
AAAGCCACGTTTCATGGGAAGAGGCCTATGCCTGTTTTCGCAAAACGGTATTGGATGTGGTTGATGCATAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT202994 WP_000362050.1 NZ_CP075116:c4496248-4495958 [Salmonella enterica subsp. enterica serovar Stanleyville]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT202994 NZ_CP099809:c3152203-3151808 [Yersinia ruckeri]
ATGACTACAAAAGCTCGTATTCAGTTACGACTGAAACGCTCAAAGCGTTATGTTTTCACTCGTGACGATTTCAAAGATCT
TGCTGGCTACGACCAAATTGGTAGAGCACTGCGTGAACTGGTGAAGGAAGGGCAGCTGCTGAAAGTAGGCTATGGCGTCT
ACACCAAAGCGCGGCAAAATGTGATTACCGGTAAGTTGATGCCTGCGGCTCCCGGAGGTTCGGCTGCGGTAGTGATTGAG
GCGTTGGAACGTCTGAAAGTGGATTACCGCTTGGTTGGAGCAACAAGCGCCTATAATAGCGGTAAATCCACTCAGATCCC
CGCTTCACTGGAAATCAAAACCTCACCACGTTTTAAGAGGACATTGTCAGTAGGGAGCAGCAAACTAAATGGATGA

Structures

Toxin

• AlphaFold DB: A0A0R9NS64