Detailed information of TA system TA202973

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DinJ-YafQ (relBE)/YafQ-RelB
• Location: 366646..367184
• Replicon: chromosome
• Accession: NZ_CP075116
• Organism: Salmonella enterica subsp. enterica serovar Stanleyville strain CFSAN059881

Toxin (Protein)

• Gene name: yafQ
• Uniprot ID: A0A8E7RBX8
• Locus tag: CCO40_RS01670
• Protein ID: WP_001682450.1
• Coordinates: 366909..367184 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: A0A7U1KUN1
• Locus tag: CCO40_RS01665
• Protein ID: WP_000729714.1
• Coordinates: 366646..366906 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCO40_RS01650 (362399)	362399..363952	+	1554	WP_000013007.1	TROVE domain-containing protein	-
CCO40_RS01655 (364300)	364300..365514	+	1215	WP_001105530.1	RNA-splicing ligase RtcB	-
CCO40_RS01660 (365518)	365518..366537	+	1020	WP_045718344.1	RNA 3'-terminal phosphate cyclase	-
CCO40_RS01665 (366646)	366646..366906	+	261	WP_000729714.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
CCO40_RS01670 (366909)	366909..367184	+	276	WP_001682450.1	type II toxin-antitoxin system YafQ family toxin	Toxin
CCO40_RS01675 (367272)	367272..369977	-	2706	WP_000907043.1	HTH-type transcriptional regulator MalT	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (4-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-84)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10605.16 Da
• Isoelectric Point: 8.9063

>T202973 WP_001682450.1 NZ_CP075116:366909-367184 [Salmonella enterica subsp. enterica serovar Stanleyville]
MGQREIEYSGQFQKDVKRAQKRHKDVGKLKTLMTLLIHHPFPLPAIYKDHPLQGSYSGYRDAHIGPDWILVDKITDECLR
FERTGTHADLF

Nucleotide

• Length: 276 bp

>T202973 NZ_CP099801:250012-250362 [Bacillus paranthracis]
TTGTTTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGCGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCAACGGTGATTGTAGCGGCTATTACTGCACAGATTCAAAAAG
CGAAATTACCCACTCATGTGGAAATTGATGCGAAAAAGTACGGTTTTGAGAGAGATTCTGTTATTTTACTTGAGCAGATT
CGAACAATCGATAAGCAGCGCTTAACGGACAAAATCACTCACTTAGATGAAGTGATGATGATTCGTGTAGATGAAGCGCT
ACAAATTAGTTTAGGACTAATAGATTTTTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9445.82 Da
• Isoelectric Point: 4.6028

>AT202973 WP_000729714.1 NZ_CP075116:366646-366906 [Salmonella enterica subsp. enterica serovar Stanleyville]
MAANALVRARIDETLKNQAADVLAEMGLTISDLIRITLTKVAREKALPFDLRIPNELTSRTIENSEAGVDIHKAKDADDL
FDQLGI

Nucleotide

• Length: 261 bp

>AT202973 NZ_CP099801:249720-250007 [Bacillus paranthracis]
GTGTCCGAATCAAGTGTAACTACTGAAATCGTGGTTCGGTTGCCAAAGCAAATGGTAACGGAATTGGACGGAATTGGAAA
ACAAGAGAATAAGAATCGCCATGAACTAATTTGCCAGGCAACACAACTGTTATTGCGTCAACATAAGACGAAGAAACGCT
ACCAACATGAATCAATGCGACGTGGGTACATTGAAATGGGAAAAATTAATCTTGGTATTGCATCTGAAGCTTTCTTAGCA
GAGTATGAAGCAGCTCATACAGTAGAACGCTTAGTTAGCGGGGGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A7U1KUN1