Detailed information of TA system TA202970

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 4382007..4382761
• Replicon: chromosome
• Accession: NZ_CP075115
• Organism: Salmonella enterica subsp. enterica serovar Eastbourne strain CFSAN059883

Toxin (Protein)

• Gene name: higB
• Uniprot ID: B5F003
• Locus tag: CCO38_RS20970
• Protein ID: WP_000558166.1
• Coordinates: 4382007..4382318 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: CCO38_RS20975
• Protein ID: WP_001259011.1
• Coordinates: 4382315..4382761 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCO38_RS20940 (4377665)	4377665..4378567	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
CCO38_RS20945 (4378564)	4378564..4379199	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
CCO38_RS20950 (4379196)	4379196..4380125	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
CCO38_RS20955 (4380172)	4380172..4380462	-	291	WP_000362050.1	DNA-binding transcriptional regulator	-
CCO38_RS20960 (4380463)	4380463..4380774	-	312	WP_001159633.1	cytotoxic translational repressor of toxin-antitoxin stability system	-
CCO38_RS20965 (4380992)	4380992..4381921	+	930	WP_001127693.1	alpha/beta hydrolase	-
CCO38_RS20970 (4382007)	4382007..4382318	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	Toxin
CCO38_RS20975 (4382315)	4382315..4382761	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	Antitoxin
CCO38_RS20980 (4382776)	4382776..4383717	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
CCO38_RS20985 (4383762)	4383762..4384199	-	438	WP_000560969.1	D-aminoacyl-tRNA deacylase	-
CCO38_RS20990 (4384196)	4384196..4385068	-	873	WP_000921423.1	virulence factor BrkB family protein	-
CCO38_RS20995 (4385062)	4385062..4385661	-	600	WP_000965695.1	glucose-1-phosphatase	-
CCO38_RS21000 (4385852)	4385852..4386655	-	804	WP_000059693.1	DeoR/GlpR family DNA-binding transcription regulator	-
CCO38_RS21005 (4386689)	4386689..4387585	-	897	WP_001636271.1	sugar kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, mRNA interferase HigB (21-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (93-146)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12432.40 Da
• Isoelectric Point: 9.5334

>T202970 WP_000558166.1 NZ_CP075115:4382007-4382318 [Salmonella enterica subsp. enterica serovar Eastbourne]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Nucleotide

• Length: 312 bp

>T202970 NZ_CP099798:c4399208-4398453 [Pseudomonas aeruginosa]
GTGAGCGAGATCTGGCGACAGTGCAAGGGTGAGCGGCATATCCGACCGCTCCAGGGGCGCCTGGTGCGGTTGGTGGAGAG
CCAGGAGCAGGTGGCGACCCTGCAATTGGTCGACACCCTGGAAGAACAGGCGTTGCTCGAGGAACTGCTCGAGTCGAGCA
AGCCGCCGGTGCCGGCGGATGCCGAGCCATTGCATTACCTGTTGAAGACCCCGTTCCGTTATCCGCCCTTGCGCTGGGGG
TCGCGGTTTGGCCGTCGCCACGAGCCAAGCCTGTTCTACGCCGCGCTGAAGCTGGAAACGGCCATGGCCGAAAGCGCGTA
TTACCGTTGCGTCCTGTGGAGTGGCATGGTGGTGCCGCCACCGAGCGGGAGGATTCTGTCCGAGCACGCTTCGTTCGAGG
CGGGCTGGAAGGTGGAGCGGGGAATCCGTCTGCAGGCGCCGCCTTTCTCCGATCACGAGGCTGCGCTGACCGACATCGCC
GACTACCGCGCTCCCCAGGAACTGGGAAGTGCCATGCGCAGCGCCGGGGTGCAGGCATTCGAATACCGTTCGGCGCGTTG
CCCGGAGCGCGGCTGCAATGTCGCCCTGTTCACGCCCGCGGCCTTCACCGAAAAGCGTCCTCGCAACCTGACGCCCTGGC
TGTGCGAAACCACGGCCGGTTACGTGGCCTTCAAGCCGGCGCATGTGCCGGGGTCGCCGAAAATCTTCTCCTGGGAGCTG
TTCCTGGTGGACGGAAAGTTGCCGCATCCGGCGTGA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16734.08 Da
• Isoelectric Point: 6.6451

>AT202970 WP_001259011.1 NZ_CP075115:4382315-4382761 [Salmonella enterica subsp. enterica serovar Eastbourne]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Nucleotide

• Length: 447 bp

>AT202970 NZ_CP099798:c4399711-4399343 [Pseudomonas aeruginosa]
ATGAGCGCTCTCATCAAGGAACGTCCCAGCGCCGATGCCGTCCTGGCCAAGGCCGTCCTGGCCGCGCGCGAGCAATTGGG
GCTGACGCAGCTCGAACTGGCCGGCATCGTCGGCGTCGATCGCAGCGCCATCAGCCGCTGGAAGACCCAGGGCTTGCGGG
TGGACAGCAAGACCGGCGAGCTGGCTCTGCTGCTGGTGCGAGTCTATCGCGCACTGTATGCCCTGTTCGGCGGGCAGCAG
GAGGACATGCGCCACTTCCTGCGCACTCCCAACCATCACCTGGCGGGCGAGCCGCTGGCACTGATGGGACAGGTGCAGGG
CCTGGTTCATGTGCTGGAATACCTCGATGCGATCCGCGGCAAGGTCTGA

Structures

Toxin

• AlphaFold DB: A0A0R9ME90