Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 4654138..4654892 | Replicon | chromosome |
| Accession | NZ_CP075113 | ||
| Organism | Salmonella enterica subsp. enterica serovar Dublin strain CFSAN059898 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A5Z3FVU6 |
| Locus tag | CCO47_RS22640 | Protein ID | WP_000558169.1 |
| Coordinates | 4654138..4654449 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | CCO47_RS22645 | Protein ID | WP_001259012.1 |
| Coordinates | 4654446..4654892 (+) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CCO47_RS22610 (4649796) | 4649796..4650698 | + | 903 | WP_000331367.1 | formate dehydrogenase subunit beta | - |
| CCO47_RS22615 (4650695) | 4650695..4651330 | + | 636 | WP_000829025.1 | formate dehydrogenase cytochrome b556 subunit | - |
| CCO47_RS22620 (4651327) | 4651327..4652256 | + | 930 | WP_000027737.1 | formate dehydrogenase accessory protein FdhE | - |
| CCO47_RS22625 (4652303) | 4652303..4652593 | - | 291 | WP_000362050.1 | DNA-binding transcriptional regulator | - |
| CCO47_RS22630 (4652594) | 4652594..4652905 | - | 312 | WP_001159635.1 | cytotoxic translational repressor of toxin-antitoxin stability system | - |
| CCO47_RS22635 (4653123) | 4653123..4654052 | + | 930 | WP_001127708.1 | alpha/beta hydrolase | - |
| CCO47_RS22640 (4654138) | 4654138..4654449 | + | 312 | WP_000558169.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| CCO47_RS22645 (4654446) | 4654446..4654892 | + | 447 | WP_001259012.1 | type II toxin-antitoxin system HigA family antitoxin | Antitoxin |
| CCO47_RS22650 (4654907) | 4654907..4655848 | - | 942 | WP_024132413.1 | fatty acid biosynthesis protein FabY | - |
| CCO47_RS22655 (4655893) | 4655893..4656330 | - | 438 | WP_000560969.1 | D-aminoacyl-tRNA deacylase | - |
| CCO47_RS22660 (4656327) | 4656327..4657199 | - | 873 | WP_000921423.1 | virulence factor BrkB family protein | - |
| CCO47_RS22665 (4657193) | 4657193..4657792 | - | 600 | WP_000965695.1 | glucose-1-phosphatase | - |
| CCO47_RS22670 (4657983) | 4657983..4658786 | - | 804 | WP_000059693.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
| CCO47_RS22675 (4658820) | 4658820..4659716 | - | 897 | WP_001575213.1 | sugar kinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12450.37 Da Isoelectric Point: 9.2536
>T202950 WP_000558169.1 NZ_CP075113:4654138-4654449 [Salmonella enterica subsp. enterica serovar Dublin]
VHVISRKPFNEAMLMYPNHELDLTELLNVLEKKTFTQPEEMKRYIPSLDNFKHRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
VHVISRKPFNEAMLMYPNHELDLTELLNVLEKKTFTQPEEMKRYIPSLDNFKHRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
Download Length: 312 bp
>T202950 NZ_CP099754:c4250145-4249831 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATCGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAATC
CAATCCTTTTACTGGTAGATGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCACACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATCGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAATC
CAATCCTTTTACTGGTAGATGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCACACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA
Antitoxin
Download Length: 149 a.a. Molecular weight: 16750.08 Da Isoelectric Point: 6.6451
>AT202950 WP_001259012.1 NZ_CP075113:4654446-4654892 [Salmonella enterica subsp. enterica serovar Dublin]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKSLN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKSLN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
Download Length: 447 bp
>AT202950 NZ_CP099754:c4250381-4250148 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACA
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACA
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|