Detailed information of TA system TA202949

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4652303..4652905
• Replicon: chromosome
• Accession: NZ_CP075113
• Organism: Salmonella enterica subsp. enterica serovar Dublin strain CFSAN059898

Toxin (Protein)

• Gene name: higB
• Uniprot ID: M7S4R6
• Locus tag: CCO47_RS22630
• Protein ID: WP_001159635.1
• Coordinates: 4652594..4652905 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: CCO47_RS22625
• Protein ID: WP_000362050.1
• Coordinates: 4652303..4652593 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCO47_RS22610 (4649796)	4649796..4650698	+	903	WP_000331367.1	formate dehydrogenase subunit beta	-
CCO47_RS22615 (4650695)	4650695..4651330	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
CCO47_RS22620 (4651327)	4651327..4652256	+	930	WP_000027737.1	formate dehydrogenase accessory protein FdhE	-
CCO47_RS22625 (4652303)	4652303..4652593	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
CCO47_RS22630 (4652594)	4652594..4652905	-	312	WP_001159635.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
CCO47_RS22635 (4653123)	4653123..4654052	+	930	WP_001127708.1	alpha/beta hydrolase	-
CCO47_RS22640 (4654138)	4654138..4654449	+	312	WP_000558169.1	type II toxin-antitoxin system HigB family toxin	-
CCO47_RS22645 (4654446)	4654446..4654892	+	447	WP_001259012.1	type II toxin-antitoxin system HigA family antitoxin	-
CCO47_RS22650 (4654907)	4654907..4655848	-	942	WP_024132413.1	fatty acid biosynthesis protein FabY	-
CCO47_RS22655 (4655893)	4655893..4656330	-	438	WP_000560969.1	D-aminoacyl-tRNA deacylase	-
CCO47_RS22660 (4656327)	4656327..4657199	-	873	WP_000921423.1	virulence factor BrkB family protein	-
CCO47_RS22665 (4657193)	4657193..4657792	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12340.30 Da
• Isoelectric Point: 9.4460

>T202949 WP_001159635.1 NZ_CP075113:c4652905-4652594 [Salmonella enterica subsp. enterica serovar Dublin]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T202949 NZ_CP099754:c4026589-4026191 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACAGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT202949 WP_000362050.1 NZ_CP075113:c4652593-4652303 [Salmonella enterica subsp. enterica serovar Dublin]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT202949 NZ_CP099754:c4026885-4026592 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTTGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAACTGGTTAAGGCGCGCTTCCGTCCGAGTGCCGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Structures

Toxin

• AlphaFold DB: A0A3V2JK97