Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4602103..4602857 Replicon chromosome
Accession NZ_CP075112
Organism Salmonella enterica subsp. enterica serovar Corvallis strain CFSAN059903

Toxin (Protein)


Gene name higB Uniprot ID A0A5V1GRS6
Locus tag CCO42_RS21935 Protein ID WP_063809159.1
Coordinates 4602103..4602414 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CCO42_RS21940 Protein ID WP_001259011.1
Coordinates 4602411..4602857 (+) Length 149 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCO42_RS21905 (4597769) 4597769..4598671 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
CCO42_RS21910 (4598668) 4598668..4599303 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
CCO42_RS21915 (4599300) 4599300..4600229 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
CCO42_RS21920 (4600267) 4600267..4600641 - 375 WP_000238494.1 type II toxin-antitoxin system VapC family toxin -
CCO42_RS21925 (4600641) 4600641..4600883 - 243 WP_001523745.1 CopG family transcriptional regulator -
CCO42_RS21930 (4601088) 4601088..4602017 + 930 WP_063809158.1 alpha/beta hydrolase -
CCO42_RS21935 (4602103) 4602103..4602414 + 312 WP_063809159.1 type II toxin-antitoxin system HigB family toxin Toxin
CCO42_RS21940 (4602411) 4602411..4602857 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
CCO42_RS21945 (4602872) 4602872..4603813 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
CCO42_RS21950 (4603858) 4603858..4604295 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
CCO42_RS21955 (4604292) 4604292..4605164 - 873 WP_000921423.1 virulence factor BrkB family protein -
CCO42_RS21960 (4605158) 4605158..4605757 - 600 WP_000965695.1 glucose-1-phosphatase -
CCO42_RS21965 (4605948) 4605948..4606751 - 804 WP_000059693.1 DeoR/GlpR family DNA-binding transcription regulator -
CCO42_RS21970 (4606785) 4606785..4607681 - 897 WP_001520529.1 sugar kinase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 104 a.a.        Molecular weight: 12458.43 Da        Isoelectric Point: 9.4811

>T202926 WP_063809159.1 NZ_CP075112:4602103-4602414 [Salmonella enterica subsp. enterica serovar Corvallis]
VYVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Download         Length: 312 bp

>T202926 NZ_CP099752:c2782682-2782371 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTTTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16734.08 Da        Isoelectric Point: 6.6451

>AT202926 WP_001259011.1 NZ_CP075112:4602411-4602857 [Salmonella enterica subsp. enterica serovar Corvallis]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT202926 NZ_CP099752:c2782370-2782080 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A5V1GRS6


Antitoxin

Source ID Structure

References