Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/Tad-HTH_37 |
| Location | 1850758..1851385 | Replicon | chromosome |
| Accession | NZ_CP075110 | ||
| Organism | Salmonella enterica strain CFSAN060804 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A5Y2FSH1 |
| Locus tag | CIC27_RS24200 | Protein ID | WP_024131287.1 |
| Coordinates | 1851056..1851385 (-) | Length | 110 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | CIC27_RS24195 | Protein ID | WP_000147078.1 |
| Coordinates | 1850758..1851066 (-) | Length | 103 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CIC27_RS08755 (1846292) | 1846292..1847119 | - | 828 | WP_000080416.1 | DUF2303 family protein | - |
| CIC27_RS08760 (1847177) | 1847177..1847547 | - | 371 | Protein_1721 | hypothetical protein | - |
| CIC27_RS24185 (1847771) | 1847771..1847890 | - | 120 | Protein_1722 | hypothetical protein | - |
| CIC27_RS08765 (1848087) | 1848087..1848311 | + | 225 | WP_023891434.1 | hypothetical protein | - |
| CIC27_RS08770 (1848274) | 1848274..1848612 | - | 339 | WP_001067432.1 | ClpX C4-type zinc finger protein | - |
| CIC27_RS08775 (1848817) | 1848817..1849512 | - | 696 | WP_001020636.1 | helix-turn-helix transcriptional regulator | - |
| CIC27_RS08780 (1849610) | 1849610..1849834 | + | 225 | WP_001191666.1 | helix-turn-helix transcriptional regulator | - |
| CIC27_RS08785 (1849863) | 1849863..1850417 | + | 555 | WP_000509731.1 | YmfL family putative regulatory protein | - |
| CIC27_RS24190 (1850563) | 1850563..1850739 | + | 177 | WP_000281065.1 | DUF4222 domain-containing protein | - |
| CIC27_RS24195 (1850758) | 1850758..1851066 | - | 309 | WP_000147078.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| CIC27_RS24200 (1851056) | 1851056..1851385 | - | 330 | WP_024131287.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| CIC27_RS24205 (1851299) | 1851299..1852264 | + | 966 | WP_223196747.1 | Rha family phage regulatory protein | - |
| CIC27_RS08795 (1852261) | 1852261..1852485 | + | 225 | WP_000620702.1 | hypothetical protein | - |
| CIC27_RS08800 (1852482) | 1852482..1853456 | + | 975 | WP_000096529.1 | conserved phage C-terminal domain-containing protein | - |
| CIC27_RS08805 (1853453) | 1853453..1853926 | + | 474 | WP_000054227.1 | PerC family transcriptional regulator | - |
| CIC27_RS08810 (1853923) | 1853923..1854804 | + | 882 | WP_085379607.1 | Dam family site-specific DNA-(adenine-N6)-methyltransferase | - |
| CIC27_RS08815 (1854813) | 1854813..1855202 | + | 390 | WP_000779148.1 | RusA family crossover junction endodeoxyribonuclease | - |
| CIC27_RS08820 (1855219) | 1855219..1856079 | + | 861 | WP_001061452.1 | KilA-N domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1820032..1889934 | 69902 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 110 a.a. Molecular weight: 12781.80 Da Isoelectric Point: 9.8238
>T202889 WP_024131287.1 NZ_CP075110:c1851385-1851056 [Salmonella enterica]
MNYTIEYYNEEVRIEVDQLPLSMRARYQHLVERMKVYGSNLGEPHTSAFGDGLFELRIKGSDGIARVFYCTLAGKRIVML
HSFIKKTQKTPVAERKKAETRMKEVKHDW
MNYTIEYYNEEVRIEVDQLPLSMRARYQHLVERMKVYGSNLGEPHTSAFGDGLFELRIKGSDGIARVFYCTLAGKRIVML
HSFIKKTQKTPVAERKKAETRMKEVKHDW
Download Length: 330 bp
>T202889 NZ_CP099743:c4633046-4632513 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA
Antitoxin
Download Length: 103 a.a. Molecular weight: 11110.77 Da Isoelectric Point: 7.0152
>AT202889 WP_000147078.1 NZ_CP075110:c1851066-1850758 [Salmonella enterica]
MTGKRNAPTITHDEMAAKWMEDPAFKAEYDAIADEFALLDEMLAARKEAGLTQAEVAERMGTKATAITRMESNLAAGVSG
PSFTTLKKFAQATGKKLQIRFV
MTGKRNAPTITHDEMAAKWMEDPAFKAEYDAIADEFALLDEMLAARKEAGLTQAEVAERMGTKATAITRMESNLAAGVSG
PSFTTLKKFAQATGKKLQIRFV
Download Length: 309 bp
>AT202889 NZ_CP099743:c4633323-4633057 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAGTCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAGTCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|