202885

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4562688..4563290 Replicon chromosome
Accession NZ_CP075109
Organism Salmonella enterica strain CFSAN060807

Toxin (Protein)


Gene name higB Uniprot ID M7S4R6
Locus tag CIC24_RS21970 Protein ID WP_001159635.1
Coordinates 4562979..4563290 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CIC24_RS21965 Protein ID WP_000362050.1
Coordinates 4562688..4562978 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CIC24_RS21950 (4560181) 4560181..4561083 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
CIC24_RS21955 (4561080) 4561080..4561715 + 636 WP_000829028.1 formate dehydrogenase cytochrome b556 subunit -
CIC24_RS21960 (4561712) 4561712..4562641 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
CIC24_RS21965 (4562688) 4562688..4562978 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
CIC24_RS21970 (4562979) 4562979..4563290 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
CIC24_RS21975 (4563508) 4563508..4564437 + 930 WP_001127706.1 alpha/beta hydrolase -
CIC24_RS21980 (4564523) 4564523..4564834 + 312 WP_000558162.1 type II toxin-antitoxin system HigB family toxin -
CIC24_RS21985 (4564831) 4564831..4565277 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin -
CIC24_RS21990 (4565292) 4565292..4566233 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
CIC24_RS21995 (4566278) 4566278..4566715 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
CIC24_RS22000 (4566712) 4566712..4567584 - 873 WP_000921423.1 virulence factor BrkB family protein -
CIC24_RS22005 (4567578) 4567578..4568177 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12340.30 Da        Isoelectric Point: 9.4460

>T202885 WP_001159635.1 NZ_CP075109:c4563290-4562979 [Salmonella enterica]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

>T202885 NZ_CP099743:1876046-1876148 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT202885 WP_000362050.1 NZ_CP075109:c4562978-4562688 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp

>AT202885 NZ_CP099743:c1876155-1876010 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JK97

Antitoxin

Source ID Structure

References