202866

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1876993..1877653 Replicon chromosome
Accession NZ_CP075109
Organism Salmonella enterica strain CFSAN060807

Toxin (Protein)


Gene name higB Uniprot ID A0A623V7Z2
Locus tag CIC24_RS08900 Protein ID WP_000269842.1
Coordinates 1876993..1877346 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CIC24_RS08905 Protein ID WP_000533827.1
Coordinates 1877351..1877653 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CIC24_RS08875 (1873058) 1873058..1873813 + 756 WP_001089670.1 multiubiquitin domain-containing protein -
CIC24_RS08880 (1873788) 1873788..1874972 + 1185 WP_076741638.1 ThiF family adenylyltransferase -
CIC24_RS08885 (1874966) 1874966..1875430 + 465 WP_001660343.1 DUF6527 family protein -
CIC24_RS08890 (1875811) 1875811..1876278 + 468 WP_000201266.1 hypothetical protein -
CIC24_RS08895 (1876275) 1876275..1876496 + 222 WP_000813787.1 helix-turn-helix transcriptional regulator -
CIC24_RS08900 (1876993) 1876993..1877346 + 354 WP_000269842.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CIC24_RS08905 (1877351) 1877351..1877653 + 303 WP_000533827.1 XRE family transcriptional regulator Antitoxin
CIC24_RS08910 (1878159) 1878159..1879043 + 885 WP_000511750.1 integrase domain-containing protein -
CIC24_RS08915 (1879912) 1879912..1881174 - 1263 WP_076741637.1 integrase arm-type DNA-binding domain-containing protein -
CIC24_RS08925 (1881512) 1881512..1882309 - 798 WP_000598920.1 DgsA anti-repressor MtfA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1875811..1890329 14518


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13476.36 Da        Isoelectric Point: 9.9199

>T202866 WP_000269842.1 NZ_CP075109:1876993-1877346 [Salmonella enterica]
VWTIKTTDTFDRWFASLNDTNRVSVLAALLVLREKGPGLSRPYADTVRGSRYSNMKELRIQSRGEPIRAFFAFDPTRTGI
VLCAGNKVGNEKRFYDEMLPVADREFTNWLNTLKEKE

Download         Length: 354 bp

>T202866 NZ_CP099723:c116115-115966 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11040.81 Da        Isoelectric Point: 5.7316

>AT202866 WP_000533827.1 NZ_CP075109:1877351-1877653 [Salmonella enterica]
MGRTLEQLIADEKPEVVAEAQAMATDILLNIHLAELREKVQKTQVEMAQALGIRQPTVAGMEKPGRDLKLSTLKRYVEAT
GGKLRLDVELPDGSHYGFVL

Download         Length: 303 bp

>AT202866 NZ_CP099723:116159-116220 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A623V7Z2

Antitoxin

Source ID Structure

References