Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4474654..4475256 Replicon chromosome
Accession NZ_CP075108
Organism Salmonella enterica strain CFSAN060808

Toxin (Protein)


Gene name higB Uniprot ID V7IUJ1
Locus tag CIC23_RS21470 Protein ID WP_001159632.1
Coordinates 4474945..4475256 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CIC23_RS21465 Protein ID WP_000362050.1
Coordinates 4474654..4474944 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CIC23_RS21450 (4472147) 4472147..4473049 + 903 WP_000331362.1 formate dehydrogenase subunit beta -
CIC23_RS21455 (4473046) 4473046..4473681 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
CIC23_RS21460 (4473678) 4473678..4474607 + 930 WP_052929816.1 formate dehydrogenase accessory protein FdhE -
CIC23_RS21465 (4474654) 4474654..4474944 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
CIC23_RS21470 (4474945) 4474945..4475256 - 312 WP_001159632.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
CIC23_RS21475 (4475474) 4475474..4476403 + 930 WP_001127705.1 alpha/beta hydrolase -
CIC23_RS21480 (4476489) 4476489..4476800 + 312 WP_023261623.1 type II toxin-antitoxin system HigB family toxin -
CIC23_RS21485 (4476797) 4476797..4477243 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
CIC23_RS21490 (4477258) 4477258..4478199 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
CIC23_RS21495 (4478244) 4478244..4478681 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
CIC23_RS21500 (4478678) 4478678..4479550 - 873 WP_000921423.1 virulence factor BrkB family protein -
CIC23_RS21505 (4479544) 4479544..4480143 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12342.27 Da        Isoelectric Point: 9.4460

>T202860 WP_001159632.1 NZ_CP075108:c4475256-4474945 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGSRGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

>T202860 NZ_CP099721:3979958-3980110 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT202860 WP_000362050.1 NZ_CP075108:c4474944-4474654 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp

>AT202860 NZ_CP099721:c3979909-3979852 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4U7VQ31

Antitoxin

Source ID Structure

References