Detailed information of TA system TA202841

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 4300542..4301296
• Replicon: chromosome
• Accession: NZ_CP075107
• Organism: Salmonella enterica strain CFSAN060809

Toxin (Protein)

• Gene name: higB
• Uniprot ID: B5F003
• Locus tag: CIC22_RS20480
• Protein ID: WP_000558166.1
• Coordinates: 4300542..4300853 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: CIC22_RS20485
• Protein ID: WP_001259009.1
• Coordinates: 4300850..4301296 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CIC22_RS20450 (4296200)	4296200..4297102	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
CIC22_RS20455 (4297099)	4297099..4297734	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
CIC22_RS20460 (4297731)	4297731..4298660	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
CIC22_RS20465 (4298707)	4298707..4298997	-	291	WP_000362050.1	DNA-binding transcriptional regulator	-
CIC22_RS20470 (4298998)	4298998..4299309	-	312	WP_001159631.1	cytotoxic translational repressor of toxin-antitoxin stability system	-
CIC22_RS20475 (4299527)	4299527..4300456	+	930	WP_220541834.1	alpha/beta hydrolase	-
CIC22_RS20480 (4300542)	4300542..4300853	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	Toxin
CIC22_RS20485 (4300850)	4300850..4301296	+	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	Antitoxin
CIC22_RS20490 (4301311)	4301311..4302252	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
CIC22_RS20495 (4302297)	4302297..4302734	-	438	WP_000560974.1	D-aminoacyl-tRNA deacylase	-
CIC22_RS20500 (4302731)	4302731..4303603	-	873	WP_000921423.1	virulence factor BrkB family protein	-
CIC22_RS20505 (4303597)	4303597..4304196	-	600	WP_000965695.1	glucose-1-phosphatase	-
CIC22_RS20510 (4304387)	4304387..4305190	-	804	WP_000059693.1	DeoR/GlpR family DNA-binding transcription regulator	-
CIC22_RS20515 (4305224)	4305224..4306120	-	897	WP_001520529.1	sugar kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, mRNA interferase HigB (21-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (93-146)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12432.40 Da
• Isoelectric Point: 9.5334

>T202841 WP_000558166.1 NZ_CP075107:4300542-4300853 [Salmonella enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Nucleotide

• Length: 312 bp

>T202841 NZ_CP099715:c20498-20241 [Dietzia kunjamensis]
ATGAAGACAATGAGCTACACCGAGTCCCGGGCCCGCTACGCCGAGGTCCTCGACGGGGTCACCAACGACCGCGAAGAAGT
CATCATCACCCGCGCCGGCCACGAACCGGTGGTGATGGTCTCCCTCGACGACTACGAATCCCTGCGCGAGACCGCCCACC
TCATGCGATCACCGGCCAACGCACGACGCCTGCTCGATGCGATGGAGCGACTCGAGTCCGGCCGCGGACAGGCACGCGAC
CTACTCGACGCCGACTGA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16720.06 Da
• Isoelectric Point: 6.6451

>AT202841 WP_001259009.1 NZ_CP075107:4300850-4301296 [Salmonella enterica]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Nucleotide

• Length: 447 bp

>AT202841 NZ_CP099715:c20239-19982 [Dietzia kunjamensis]
GTGCTACTCGTCTGGGACGACAACGCCTGGCAGGACTACCTCTGGTGGCAACAACAGGACCGCAAGATCCTCAAACGCAT
CAACCTGCTCCTGCAGGACATCACCCGCAACGGCAACGAGGGAATCGGCAAACCCGAACCCCTCAAGTACGACTTCGCCG
GATACTGGTCCAGACGCATCACCGACGAGCACCGACTCGTCTACAAAGTCACCGACACCGAAGTCCGAATCGCCACCTGC
CGCTACCACTACGGGTAA

Structures

Toxin

• AlphaFold DB: A0A0R9ME90