Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 4615482..4616236 | Replicon | chromosome |
| Accession | NZ_CP075106 | ||
| Organism | Salmonella enterica strain CFSAN064276 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | B5F003 |
| Locus tag | CBI76_RS22335 | Protein ID | WP_000558166.1 |
| Coordinates | 4615482..4615793 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | CBI76_RS22340 | Protein ID | WP_031609809.1 |
| Coordinates | 4615790..4616236 (+) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CBI76_RS22305 (4611148) | 4611148..4612050 | + | 903 | WP_000331364.1 | formate dehydrogenase subunit beta | - |
| CBI76_RS22310 (4612047) | 4612047..4612682 | + | 636 | WP_000829025.1 | formate dehydrogenase cytochrome b556 subunit | - |
| CBI76_RS22315 (4612679) | 4612679..4613608 | + | 930 | WP_000027730.1 | formate dehydrogenase accessory protein FdhE | - |
| CBI76_RS22320 (4613646) | 4613646..4614020 | - | 375 | WP_023243564.1 | type II toxin-antitoxin system VapC family toxin | - |
| CBI76_RS22325 (4614020) | 4614020..4614262 | - | 243 | WP_001523745.1 | CopG family transcriptional regulator | - |
| CBI76_RS22330 (4614467) | 4614467..4615396 | + | 930 | WP_001162860.1 | alpha/beta hydrolase | - |
| CBI76_RS22335 (4615482) | 4615482..4615793 | + | 312 | WP_000558166.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| CBI76_RS22340 (4615790) | 4615790..4616236 | + | 447 | WP_031609809.1 | type II toxin-antitoxin system HigA family antitoxin | Antitoxin |
| CBI76_RS22345 (4616251) | 4616251..4617192 | - | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
| CBI76_RS22350 (4617237) | 4617237..4617674 | - | 438 | WP_000560969.1 | D-aminoacyl-tRNA deacylase | - |
| CBI76_RS22355 (4617671) | 4617671..4618543 | - | 873 | WP_000921423.1 | virulence factor BrkB family protein | - |
| CBI76_RS22360 (4618537) | 4618537..4619136 | - | 600 | WP_000965695.1 | glucose-1-phosphatase | - |
| CBI76_RS22365 (4619327) | 4619327..4620130 | - | 804 | WP_000059693.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
| CBI76_RS22370 (4620164) | 4620164..4621060 | - | 897 | WP_023243565.1 | sugar kinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12432.40 Da Isoelectric Point: 9.5334
>T202823 WP_000558166.1 NZ_CP075106:4615482-4615793 [Salmonella enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
Download Length: 312 bp
>T202823 NZ_CP099705:868946-869359 [Salmonella enterica subsp. enterica serovar Typhimurium]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA
Antitoxin
Download Length: 149 a.a. Molecular weight: 16721.00 Da Isoelectric Point: 6.0016
>AT202823 WP_031609809.1 NZ_CP075106:4615790-4616236 [Salmonella enterica]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEETPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEETPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
Download Length: 447 bp
>AT202823 NZ_CP099705:868699-868965 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|